ID G1T9F9_RABIT Unreviewed; 827 AA.
AC G1T9F9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSOCUP00000013264.4};
GN Name=BCAR3 {ECO:0000313|Ensembl:ENSOCUP00000013264.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013264.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013264.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013264.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013264.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013264.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02001431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02001432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02001433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002715899.1; XM_002715853.3.
DR RefSeq; XP_008263086.1; XM_008264864.2.
DR RefSeq; XP_017201559.1; XM_017346070.1.
DR RefSeq; XP_017201560.1; XM_017346071.1.
DR AlphaFoldDB; G1T9F9; -.
DR SMR; G1T9F9; -.
DR STRING; 9986.ENSOCUP00000013264; -.
DR PaxDb; 9986-ENSOCUP00000013264; -.
DR Ensembl; ENSOCUT00000015438.4; ENSOCUP00000013264.4; ENSOCUG00000015440.4.
DR GeneID; 100352424; -.
DR KEGG; ocu:100352424; -.
DR CTD; 8412; -.
DR eggNOG; ENOG502QPX3; Eukaryota.
DR GeneTree; ENSGT00940000154130; -.
DR HOGENOM; CLU_015281_0_0_1; -.
DR InParanoid; G1T9F9; -.
DR OrthoDB; 2953960at2759; -.
DR TreeFam; TF323756; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000015440; Expressed in upper lobe of left lung and 16 other cell types or tissues.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 154..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 550..820
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 91872 MW; 7C10D0A948893DE6 CRC64;
MAAGKFASLP RNMPVSHPSP LASSMDLLSS TSPLAEHHAD AYPDASIHGT LPRKKKGPPP
IRSCDSFSHM GTLPHAKSPR QSSPRTQDVI RESPLQDWKG ETFTFRDLHL LDSTLDYVKF
SKDRHVMDRT PERLKKELEE ELLLSSEDLR SHAWYHGRIP RQVSENLMQR DGDFLVRDSL
SSPGNFVLTC QWKNLAQHFK ITRTVLRLSE AYSRVQYQFE TESFDSIPGL VRCYVGNRRP
ISQQSGAIIF QPINRTVPLR CLEERYGTTP GRARDSSLAH GRPDVTRRLS LSPGSVQARE
QSLPRGNLLR NKEKSGSQPA CLDHMQDRRA LSLKAHQSES YLPIGCKLPP QPPGVDTSPS
PNSPVFRTGS EPTLSPAVVR RVSADPRSGE ALRGSDSQLC PKPPPKPCKA PVLKAPLSPP
TQLSAEANYC ELNPACAAGG DHGVRPPLCA LGSHVQLPTA RLSEAPGSRN SGTSYLILDG
DDGARPWEPP AAQMEEGTCK EDTGEFVAPL LETVSSFRPN DFESKLLPPE NKPLETAMLK
RAKELFASHH PRVIAQHLLH TDCKVARILE VSEETRRNMG VSSGLELLTL PHGRQLRLDI
IERHNTMAIG VAVDILGCTG SLEDRAATLN RIIQVAAELK DAVGDLYSFS AIMKALEMPQ
ITRLEKTWTA LRHQYTQTAI LYEKQLKPFS KVLHEGREPT CVPPCSVSVP LLMPLVTLME
RQAVTFEGTD LWEKHDQSCE IMLNHLAAAR LMAQAADSYR ANAERMLAGF QPDEEMSEVF
KTEFQMRLLW GSKGAEVNQT ERYEKFSQIL TALSRKLEPP PAKQAEL
//
