ID G1T9N8_RABIT Unreviewed; 372 AA.
AC G1T9N8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Heat shock protein family A (Hsp70) member 8 {ECO:0000313|Ensembl:ENSOCUP00000013353.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013353.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013353.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013353.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013353.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013353.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02009545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008258553.1; XM_008260331.2.
DR AlphaFoldDB; G1T9N8; -.
DR PaxDb; 9986-ENSOCUP00000013353; -.
DR Ensembl; ENSOCUT00000015539.4; ENSOCUP00000013353.3; ENSOCUG00000015533.3.
DR GeneID; 100359012; -.
DR KEGG; ocu:100359012; -.
DR CTD; 79827; -.
DR eggNOG; KOG3866; Eukaryota.
DR GeneTree; ENSGT00950000183206; -.
DR HOGENOM; CLU_040549_0_1_1; -.
DR OMA; RYSCKVK; -.
DR OrthoDB; 4605345at2759; -.
DR TreeFam; TF330875; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000015533; Expressed in ovary and 16 other cell types or tissues.
DR ExpressionAtlas; G1T9N8; baseline.
DR GO; GO:0005881; C:cytoplasmic microtubule; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR CDD; cd20960; IgV_CAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR042454; CLMP.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44783; CXADR-LIKE MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR44783:SF1; CXADR-LIKE MEMBRANE PROTEIN; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..372
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003423125"
FT TRANSMEM 230..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..115
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 134..223
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 263..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 40903 MW; 8A1077F23A0AFFB7 CRC64;
MSPLLLLLVS YYVGTLGTHT EIKRVAEEKV TLPCHHQLGL PEKDTLDIEW LLTDNEGNQK
VVITYSSHHV YNNLTEEQKG RVAFASNFLA GDASLQIEPL KPSDEGRYTC KVKNSGRYVW
SHVILKVLVR PSKPKCELEG ALTEGSDLTL QCESSSGTKP IVYYWQRIRE KEGEDEHLPP
KSRIDYNNPG RVLLQNLTMS SSGLYQCTAG NEAGKESCVV RVTVQYVQSI GMVAGAVTGI
VAGALLIFLL VWLLIRRKDK KRYEEEERPN EIREDAEAPK ARLVKPSSSS SGSRSSRSGS
SSTRSTANSA SRSQRTLSTD AAPQPGLVTQ AYGLVGPDTK SSEPKKVHHA TLTKAETATS
MIPSQSRAFQ TV
//
