ID G1TB68_RABIT Unreviewed; 370 AA.
AC G1TB68;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Rab9 effector protein with kelch motifs {ECO:0000256|ARBA:ARBA00039295};
GN Name=RABEPK {ECO:0000313|Ensembl:ENSOCUP00000013948.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013948.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013948.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013948.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013948.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Rab9 effector required for endosome to trans-Golgi network
CC (TGN) transport. {ECO:0000256|ARBA:ARBA00037224}.
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DR RefSeq; XP_002720486.1; XM_002720440.3.
DR RefSeq; XP_008271528.1; XM_008273306.2.
DR RefSeq; XP_008271529.1; XM_008273307.2.
DR RefSeq; XP_008271530.1; XM_008273308.2.
DR AlphaFoldDB; G1TB68; -.
DR SMR; G1TB68; -.
DR STRING; 9986.ENSOCUP00000013948; -.
DR PaxDb; 9986-ENSOCUP00000013948; -.
DR Ensembl; ENSOCUT00000016226.3; ENSOCUP00000013948.3; ENSOCUG00000016229.3.
DR GeneID; 100340956; -.
DR KEGG; ocu:100340956; -.
DR CTD; 10244; -.
DR eggNOG; KOG0379; Eukaryota.
DR GeneTree; ENSGT00940000158763; -.
DR HOGENOM; CLU_045313_0_0_1; -.
DR InParanoid; G1TB68; -.
DR OrthoDB; 5474681at2759; -.
DR TreeFam; TF329153; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000016229; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011498; Kelch_2.
DR PANTHER; PTHR46647; RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS; 1.
DR PANTHER; PTHR46647:SF1; RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 370 AA; 40170 MW; 87EFB4F50F26E224 CRC64;
MKELPVLEPG DKPKKATWYT LTPHGESPCA RVGHSCSYLP PVGDAKRGKV FIVGGANPNR
SFSDVHTMDL GAHQWDRASW EGLLPRYEHA SFIPSCAPDS IWVFGGANQS GNRNCIQVLE
PETRSWNTPE VTNLPPSPRT FHTSSAAIGS QLYVFGGGER GAQPVQDVKL HVFDANTLTW
SQPETLGRPP SPRHGHVMVA AGTKLFIHGG LAGDTFYDDL HCIDISDMEW QKLSPTGAVP
AGCAAHSAVA VGKHLYVFGG MTPTGALDTM YQYHIENQHW TLLNFDTFLP PGRLDHSMCV
IPWPVTSAAE REDPAPVHCE AEKGVSDDGG MTHCGDSCEE SQTDVLLCFV FGGMNTEGEI
YDDCIVTVVD
//
