ID G1TBE8_RABIT Unreviewed; 366 AA.
AC G1TBE8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=ABI family member 3 {ECO:0000313|Ensembl:ENSOCUP00000014041.3};
GN Name=ABI3 {ECO:0000313|Ensembl:ENSOCUP00000014041.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014041.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014041.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014041.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014041.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014041.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ABI family. {ECO:0000256|ARBA:ARBA00010020}.
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DR EMBL; AAGW02039575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002719352.1; XM_002719306.3.
DR AlphaFoldDB; G1TBE8; -.
DR SMR; G1TBE8; -.
DR STRING; 9986.ENSOCUP00000014041; -.
DR PaxDb; 9986-ENSOCUP00000014041; -.
DR Ensembl; ENSOCUT00000016331.3; ENSOCUP00000014041.3; ENSOCUG00000016339.3.
DR GeneID; 100344685; -.
DR KEGG; ocu:100344685; -.
DR CTD; 51225; -.
DR eggNOG; KOG2546; Eukaryota.
DR GeneTree; ENSGT00940000161380; -.
DR HOGENOM; CLU_035421_0_0_1; -.
DR InParanoid; G1TBE8; -.
DR OrthoDB; 3028771at2759; -.
DR TreeFam; TF314303; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000016339; Expressed in blood and 20 other cell types or tissues.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0031209; C:SCAR complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0002357; P:defense response to tumor cell; IEA:Ensembl.
DR GO; GO:0010593; P:negative regulation of lamellipodium assembly; IEA:Ensembl.
DR GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:2000774; P:positive regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR CDD; cd11826; SH3_Abi; 1.
DR Gene3D; 6.10.140.1620; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR028457; ABI.
DR InterPro; IPR028455; ABI3_SH3.
DR InterPro; IPR012849; Abl-interactor_HHR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10460:SF7; ABI GENE FAMILY MEMBER 3; 1.
DR PANTHER; PTHR10460; ABL INTERACTOR FAMILY MEMBER; 1.
DR Pfam; PF07815; Abi_HHR; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 308..366
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 164..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 38775 MW; 04E402E9BFED1A31 CRC64;
MAELQQLQNL DIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS
VAYQVGNLAG NTLRMLDLQG AALRQVEARV STLGQMVNMH LEKVARREIG TLATVQQLPP
GQKVIAPESL PPLTPYYRKP LNFGCLDDVG HGIKDLSTQL SRTGTLSRKN IKTPAAPASA
TLGRPPRIPE PVQPPTVPDG RLSAASSASS LASAGSADGG GGVSAPKGQE APPPPPPLSS
LALPPPPANE VFLPPPPPEE LSPPPPAEEL PPPLDLPPPP PLDVDELGLL PPPPPGFGPE
EPSWVPAAYL EKVVTLHPYT AQKDNELSFS EGTVMYVTRR YSDGWCEGVS SEGAGFFPGN
YVEPSC
//