ID G1TCS5_RABIT Unreviewed; 1026 AA.
AC G1TCS5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Thioredoxin domain containing 11 {ECO:0000313|Ensembl:ENSOCUP00000014602.3};
GN Name=TXNDC11 {ECO:0000313|Ensembl:ENSOCUP00000014602.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014602.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014602.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014602.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014602.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014602.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02056984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002711799.2; XM_002711753.3.
DR AlphaFoldDB; G1TCS5; -.
DR SMR; G1TCS5; -.
DR STRING; 9986.ENSOCUP00000014602; -.
DR PaxDb; 9986-ENSOCUP00000014602; -.
DR Ensembl; ENSOCUT00000016995.3; ENSOCUP00000014602.3; ENSOCUG00000016994.3.
DR GeneID; 100349396; -.
DR KEGG; ocu:100349396; -.
DR CTD; 51061; -.
DR eggNOG; KOG0190; Eukaryota.
DR GeneTree; ENSGT00390000016020; -.
DR HOGENOM; CLU_010764_1_0_1; -.
DR InParanoid; G1TCS5; -.
DR OrthoDB; 4541374at2759; -.
DR TreeFam; TF323602; -.
DR Proteomes; UP000001811; Chromosome 6.
DR Bgee; ENSOCUG00000016994; Expressed in blood and 19 other cell types or tissues.
DR CDD; cd03006; PDI_a_EFP1_N; 1.
DR CDD; cd02995; PDI_a_PDI_a'_C; 1.
DR CDD; cd02981; PDI_b_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 2.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46497; THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11; 1.
DR PANTHER; PTHR46497:SF1; THIOREDOXIN DOMAIN-CONTAINING PROTEIN 11; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR SUPFAM; SSF52833; Thioredoxin-like; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 165..291
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 696..846
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..964
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 994..1012
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1026 AA; 114312 MW; 1C75AB90D783E903 CRC64;
MRAGAWPPYE PEAARSPRSR GRSHVRGGGA RAAARLTWRV RVSGRCQLRD WGATGRAGPS
GPRRRRRRYK AGDGEHVMSE CGGRGGGSSS SDDAEDEGGG GPAGSGSLSP APAGASSAGR
LRRGLRGASL MARRRPELLC GAVALGCAVL LALKFTCSRA KDVIIPAKPP VSFFSSRSPV
LDLFQGQLDY AEHIRQDSEV VLLFFYAPWC GQSIAARAEI EQAAIRLSDQ VLFVAINCWW
NQGKCRKQKH FFYFPVIYLY HRSFGPIEYK GPMSAVYIEK FVRRVMRPLL YIPSQSELLD
FLSNHEPGVL GYFEFSGSPQ PPGYLTFFTS ALHSLKKDYL GTVRFGVITN KHLAKLVSLV
HSGSVYLHRH FNTSLVFPRE VMNYTAENIY KWASENRETL FRWLRPHGGK SLLLNNELKK
GPALFLFIPF NPLAETHPLL DEITEVALEY NNCRGDHVVQ RLLQHLRRVD APVLESLSSA
PQAPLADPPL MAAAPCCNTV VLPPGHALSR THNICELCVN QSAGGVRPSS VSVPQCSFFE
MAAALDSFYL KEQAFYHVAS DSIECSNFLT SYSPFSYYTA CCRTIHRGVA GFIDSEQDGV
LDTPALAFSS VEEKCEGDVP SAVPHIEESR YRLPDVDSPG TDFTGLSCRT NKTLNIYLLD
SNLFWLYAER LGAPSSSRVK EFATIVDVKE ESHYVLDPKQ ALVKFTLESF IQNFSVLYSP
LKRHLIGSDS AQFPSQHLIT EVTTDTFWEV VLRKQDVLLL YYAPWCGFCP SLNHVFIQLA
RLLPVDMFTV ARIDVSQNDL PWEFMVDRLP TVLFFPCNRK DLSVKYPEDL PITLPNLLRF
ILHHSAPASS SQDVASPPTK DCVQSEAALQ QGHISQLQRE IQKLRAEIGS LQRAQVQVEM
QLSRARRDEH RLQREQQALE QQHRLLRRHS QQLQALHEQK SRELAALARQ LQELADASET
LLAENAWLKI LVATMERKLE GQDGAEDAAA LPQEGPDPPQ PAGAPPPPPN VSSTLASERS
NENRTE
//
