ID G1TD23_RABIT Unreviewed; 590 AA.
AC G1TD23;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Ankyrin repeat and SOCS box containing 15 {ECO:0000313|Ensembl:ENSOCUP00000014719.3};
GN Name=ASB15 {ECO:0000313|Ensembl:ENSOCUP00000014719.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014719.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014719.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014719.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014719.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014719.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; AAGW02038960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02038961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002712119.1; XM_002712073.3.
DR AlphaFoldDB; G1TD23; -.
DR SMR; G1TD23; -.
DR STRING; 9986.ENSOCUP00000014719; -.
DR PaxDb; 9986-ENSOCUP00000014719; -.
DR Ensembl; ENSOCUT00000017124.4; ENSOCUP00000014719.3; ENSOCUG00000017124.4.
DR GeneID; 100339061; -.
DR KEGG; ocu:100339061; -.
DR CTD; 142685; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000157073; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; G1TD23; -.
DR OMA; HVNDTHF; -.
DR OrthoDB; 5479200at2759; -.
DR TreeFam; TF315127; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000017124; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24178:SF44; ANKYRIN REPEAT AND SOCS BOX PROTEIN 3; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REPEAT 110..142
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 143..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 209..241
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 242..274
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 307..339
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 349..381
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..407
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 533..579
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 590 AA; 66541 MW; 9E191D0B3362DA6A CRC64;
MGDNDDFDED HLTSYDIQLS IQESIEASKN VFYPERFVPL SEQNRKLVEA IKQGHILELQ
EYVKYKYALD EADEKGWFPL HEAVVQPLQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK
AGMVENVRLL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV SSLIKHNTSL DQPCVKRWSA
MHEAAKQGRK DIIALLLRHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA
DDGASLLFEA AGSGNPDCIS LLLEYGASGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
KHAIEKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAE HISQSYDDER KTALYFAVSN
NDIHCTEVLL TAGADPNLDP LNCLLVAVRA NNHEIVRLLL SYGANVNCYF MHVNDTHFPS
AIQYALNDEV MLRLLLNNGY HVEMCFDCMH GDIFGNSFVW LEIEEEVVPG WTSCVIKDNP
FCEFITVPWM KHLVGSVIRI LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLQHL
CRLKIRRLMG LQRLCQPDLM KRLPLPPVIQ KYILFKEYDL YGQELKLPEF
//