ID G1TDB4_RABIT Unreviewed; 853 AA.
AC G1TDB4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Rho guanine nucleotide exchange factor 4 {ECO:0008006|Google:ProtNLM};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014825.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014825.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014825.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014825.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014825.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02005422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000017254.4; ENSOCUP00000014825.4; ENSOCUG00000017253.4.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00940000160622; -.
DR HOGENOM; CLU_002250_0_0_1; -.
DR TreeFam; TF316832; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000017253; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11973; SH3_ASEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 357..416
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 447..631
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 662..769
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 96552 MW; 4EBDE5FFCA39CBFD CRC64;
MSAREELHAE SPLGTGWDPA SREHVGDSAS LEPGPRLAAG GEAATPRELG GRSPSSENCH
AKTLRTTEKR LRARLALAQK TVSHFFESRV SERERTRDRP PAPLKVEDKR RPRQSSWRVF
LRSKGPPETL THDVQNEECA RGAPRNPGLT VGPSLRDLPG SENPEPWEEP PGEQPRGAQV
QKALHTEPAP RPLSSAQVAG WALPSISAEE APREALPHPR STYQRLRCSA DDLWLEKTQR
RRLEEQGQVK RKKHAGISHK GRVQGWRKTT AAAPESLDLP RSHPLSQSAP AGLNHVGRPP
HTPATAMPDG VLDTVVRADE AGSEEDLYED LHGSSHHYSH PGGGGEQLAI NELISDGSVV
CAEALWDHVT MDDQELGFKA GDVIEVMDAT NREWWWGRVA DGEGWFPASF VRXXVNQDEP
ADDEAPQAGS GGAEDGGAEA QSSKDQMRTN VINEILSTER DYIKHLRDIC EGYIRQCRKR
ADMFSEEQLR TIFGNIEDIY RCQKAFVKAL EQKFNRERPH LSELGACFLE HQADFQIYSE
YCNNHPNACV ELSRLTKLSK YVYFFEACRL LQKMIDISLD GFLLTPVQKI CKYPLQLAEL
LKYTHPQHRD FKDVEAALHA MKNVAQLINE RKRRLENIDK IAQWQSSIED WEGEDLLVRS
SELIYSGELT RVTQPQAKSQ QRMFFLFDHQ LIYCKKDLLR RDVLYYKGRL DMDSLEVVDL
DDGKDRDLHV SIKNAFRLHC GTSGDSHLLC ARKPEQKQRW LKAFAREREQ VRLDHETGFS
ITELQRKQAM LNASKQQATG KPKAIGRPGY LMRQKHPALP ASRAQQQVLV LAEPRRKPST
FWHSISRLAP FRK
//
