ID G1TDF3_RABIT Unreviewed; 644 AA.
AC G1TDF3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Atypical kinase COQ8A, mitochondrial {ECO:0000256|ARBA:ARBA00018535};
DE AltName: Full=Chaperone activity of bc1 complex-like {ECO:0000256|ARBA:ARBA00032726};
DE AltName: Full=Coenzyme Q protein 8A {ECO:0000256|ARBA:ARBA00033204};
DE AltName: Full=aarF domain-containing protein kinase 3 {ECO:0000256|ARBA:ARBA00031775};
GN Name=COQ8A {ECO:0000313|Ensembl:ENSOCUP00000014869.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014869.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014869.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014869.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014869.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014869.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004749}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000256|ARBA:ARBA00009670}.
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DR EMBL; AAGW02026632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008266363.1; XM_008268141.2.
DR RefSeq; XP_008266364.1; XM_008268142.2.
DR RefSeq; XP_008266365.1; XM_008268143.2.
DR AlphaFoldDB; G1TDF3; -.
DR Ensembl; ENSOCUT00000017305.4; ENSOCUP00000014869.2; ENSOCUG00000017305.4.
DR GeneID; 100347765; -.
DR KEGG; ocu:100347765; -.
DR CTD; 56997; -.
DR eggNOG; KOG1234; Eukaryota.
DR GeneTree; ENSGT00940000156810; -.
DR HOGENOM; CLU_006533_9_1_1; -.
DR OMA; PLDKCFD; -.
DR OrthoDB; 668390at2759; -.
DR TreeFam; TF300630; -.
DR UniPathway; UPA00232; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000017305; Expressed in heart and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd13970; ABC1_ADCK3; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR034646; ADCK3_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR43851; -; 1.
DR PANTHER; PTHR43851:SF1; ATYPICAL KINASE COQ8A, MITOCHONDRIAL; 1.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 296..535
FT /note="ABC1 atypical kinase-like"
FT /evidence="ECO:0000259|Pfam:PF03109"
FT REGION 92..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 71600 MW; 4D7512A0C1BC3FCA CRC64;
MAAMLGDAIM LAKGLIKLTR VALETHLQHL GLGGELILAA RALQSTAVEQ IGMVFGTEQG
QTAHDESSTS AESFDDLEAE LHFSGAQAAG ASGNFSEAST LDPLAPSLNP AHSEGPAPAY
VGSGPFKDAG LPGQGRVNGR LFTDPRDSFS ATGIHRRFFH QDQSPVGGLT AEDIEKARQA
KARPENKPHK QMLSERARER KVPVTRLGRL ANFGGLAVGL GFGALAEVAK KSLRPEDPTG
KKAVLDSSPF LSEANAERIV STLCKVRGAA LKLGQMLSIQ DDAFINPHLA KIFERVRQSA
DFMPLKQMTK TLNNDLGPNW RDKLEYFEER PFAAASIGQV HLARMKGGRE VAMKIQYPGV
AQSINSDVNN LMTVLNMSNM LPEGLFPEHL IDVLRRELAL ECDYEREAAC ARKFRELLKD
HPFFYVPEIV DELCSPHVLT TELVSGFPLD QAEGLSQEIR NEICYNILVL CLRELFEFHF
MQTDPNWSNF FYDPQQHKVA LLDFGATREY DRSFTDIYIQ IIRAAADRDR EAVLRKSIEM
KFLTGYEVKA MEDAHLDAIL ILGEAFASDE PFDFGTQSTT EKIHNLIPVM LKHRLIPPPE
ETYSLHRKMG GSFLICSKLK ARFPCKAMFE EAYGNYCRRK AEQQ
//
