ID G1TDP0_RABIT Unreviewed; 1060 AA.
AC G1TDP0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Integrin subunit alpha X {ECO:0000313|Ensembl:ENSOCUP00000014973.3};
GN Name=ITGAX {ECO:0000313|Ensembl:ENSOCUP00000014973.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014973.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014973.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014973.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014973.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; G1TDP0; -.
DR SMR; G1TDP0; -.
DR STRING; 9986.ENSOCUP00000014973; -.
DR PaxDb; 9986-ENSOCUP00000014973; -.
DR Ensembl; ENSOCUT00000017426.4; ENSOCUP00000014973.3; ENSOCUG00000017422.4.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000154838; -.
DR HOGENOM; CLU_004111_3_0_1; -.
DR InParanoid; G1TDP0; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000017422; Expressed in blood and 13 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1905956; P:positive regulation of endothelial tube morphogenesis; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0031643; P:positive regulation of myelination; IEA:Ensembl.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF118; INTEGRIN ALPHA-X; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 20..1060
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5023963158"
FT REPEAT 23..78
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 152..334
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 445..505
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 508..566
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 571..631
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1060 AA; 115589 MW; 30085D221F17B5E1 CRC64;
MSGARTALLL SVALASAFCF NLDTEKLTTF RMPSTGFGHS VAQYASSWVV VGAPQEITAP
NQTGGLYQCD YGSGLCVPIQ LQVPPEAVNM SLGLSLAAST SPSQLLACGP TVQHACRENM
HLTGFCFLLD QTSQQPRMFP TALQECPKLE QDIVFLIDGS GSISFSNFAT MKNFVKAVMS
QFPRPSTQFS LMQFSNEFQT HFTFNDFVSS TNPLQLLDRV YQLMGTTHTA TAILRVVDQL
FHASTGARKD ATKILIVITD GQKLDDPLGY EDVIPKAEAA GIIRYAIGVG LAFQVVSSLR
ELHDIASEPA HEHVFRVENF DALRDIQGRL KEKIFAIEGT ETMKSSAFEL EMSQEGFSAV
LTPEGPVLGA VGSFDWSGGA FLYPPGGSPT FINMSQQNVD MRDSYLGYSS QLVLWKGVQS
LVLGAPRYEH TGKVVLFTQM STHWEMRAEV TGTQIGSYFG SSLCSVDVDR DGSTDLVLIG
APHYYEQTRG GRVSVCPLPR GQAPWRCERV LRGEQGHPWG RFGAALTVLG DVNGDQLADV
AIGAPGEQEN QGAIYLFHGA PGLDMSPTHS QRIAGAQLSP TLQYFGQALS GGQDLTRDGL
MDLAVGAQGQ VLLLRTRPIL RVRVDMRFAP AEVTRSVFEC REPAASLQAL GDAFVCLQVY
ESPKNQLGEL RSSVSFDLAL DPGRLNPRAV FKETKTRSLS REQELGLDPY CEALPLLLPA
CVEDVVTPIT LRLNFSLVGM PLPSLGDLRP MLAVDAQTYF TASLPFEKNC GADHICQDDL
AISFGFSGLK ILVVGNNLEL NAEVTVRNDG EDSYGTTVTF SYPAGLSYRR VAGAQTQLQL
QPLRLTCDSV PSGSQDTRST SCSLKHLIFR GGTQITFLTT FDVSPKAELG DRLLLTANVH
EQSTKYLNFS ASEKEGSGTA QHRYQVNNLG QRDLPVSITF WVPVELNGAR VWTEVEVSHP
QNPAVQCPSE KVAPESGLLT HIHKSAVLDC SIAHCLRFRC HIPAFGIQEE LHFTLKGNLS
FAWVSQMPQK KVSVVSVAEI TFNRAVYSQV PGEEPFMRAQ
//