ID G1TDR3_RABIT Unreviewed; 691 AA.
AC G1TDR3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Erythrocyte membrane protein band 4.2 {ECO:0000313|Ensembl:ENSOCUP00000015000.3};
GN Name=EPB42 {ECO:0000313|Ensembl:ENSOCUP00000015000.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000015000.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000015000.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000015000.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000015000.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000015000.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AAGW02024585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008267335.1; XM_008269113.2.
DR AlphaFoldDB; G1TDR3; -.
DR SMR; G1TDR3; -.
DR STRING; 9986.ENSOCUP00000015000; -.
DR PaxDb; 9986-ENSOCUP00000015000; -.
DR Ensembl; ENSOCUT00000017460.4; ENSOCUP00000015000.3; ENSOCUG00000017459.4.
DR eggNOG; ENOG502R9T9; Eukaryota.
DR GeneTree; ENSGT01050000244866; -.
DR HOGENOM; CLU_013435_3_0_1; -.
DR InParanoid; G1TDR3; -.
DR OMA; NPWGRED; -.
DR OrthoDB; 5344745at2759; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000017459; Expressed in blood and 9 other cell types or tissues.
DR GO; GO:0170014; C:ankyrin-1 complex; IEA:Ensembl.
DR GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0020027; P:hemoglobin metabolic process; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590:SF44; PROTEIN 4.2; 1.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 260..353
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
SQ SEQUENCE 691 AA; 76590 MW; E8E185C469DF63F9 CRC64;
MGHTLGIMSC DLQAARNNEE HHTKAISSRR LVVRRGQSFT VLLHFRTPVR RFLPTLKKVA
LVIQTGEQPS TANRTQAIFP ISSLGDRKGW SAAVEERDDQ SWTISVTTPA DAVIGHYSLL
LQVSGRKQRL LGQFTLLFNP WNREDTVFLE NEAQRREYVL NQNGLVYLGT ADCIQEESWD
FGQFEGDVVD LSLALLSVDK QVEKWSQPVH VARVLGALLH ALKEKSVLPT PQTQAAEEGA
LLNKRRGSVP ILRQWLTGQG RPVYDGQAWV LAAVMCTVLR CLGVPARVVT TYASAQGTGG
GLLVDEYYNE EGLQNGEGQR GRVWIFQTST ECWMKRPALP QEYNGWQILY PTASGGSGVL
GACDLVPVRA IKEGILGLSP AVSDLFASVN ASCVVWKCCE DGTLELTSSN TKYVGSNIST
KAVGSDRCED ITQHYKYPEG SIQEKEVLER VQKKRMEQGK DNGIPPPSVE MADPLYLFLE
APSSLPLRGE AQLSVILVNP SDQEKAVQLT IGAQAMYYNG VLATELWREK LSLTLSANLV
KRITTSLSFS YFEPHPPENS FLRLTAMATH SKSSLSCFAQ EDVAICRPQL AIEMPETAEQ
YQPLTASVSL HNTLDAPMKD CVISILGRGL IHRERNYRLG PVWPGNMLCT QFQFTPTHLG
LHRLTVEMDC NMFQNLTNYR SVTVVAPELP A
//
