ID G1TF58_RABIT Unreviewed; 837 AA.
AC G1TF58;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=PHD finger protein 14 {ECO:0000313|Ensembl:ENSOCUP00000015548.3};
GN Name=PHF14 {ECO:0000313|Ensembl:ENSOCUP00000015548.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000015548.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000015548.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000015548.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000015548.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000015548.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02035578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TF58; -.
DR PaxDb; 9986-ENSOCUP00000015548; -.
DR Ensembl; ENSOCUT00000027251.3; ENSOCUP00000015548.3; ENSOCUG00000004678.4.
DR eggNOG; KOG0957; Eukaryota.
DR GeneTree; ENSGT00940000156923; -.
DR HOGENOM; CLU_006506_0_0_1; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000001811; Chromosome 10.
DR Bgee; ENSOCUG00000004678; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15674; ePHD_PHF14; 1.
DR CDD; cd15561; PHD1_PHF14; 1.
DR CDD; cd15562; PHD2_PHF14; 1.
DR Gene3D; 2.30.30.1150; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF150; PHD FINGER PROTEIN 14; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 330..391
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 393..510
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 30..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 641..689
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 77..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..267
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 94115 MW; D35E22C1C596D6B2 CRC64;
MAVSLLTVDR SSKRRQVKPL AASLLEALDY DSSDDSDFKV GDASDSEGSG NGSEDPSKDS
GEGSCSDSEE NILEEELNED TKVKEEQLKN CAVEEILSSE KQLIKMEKKE DEETGEKPRK
KKEKEKEKEK EKEKEKEKEK EREKEKEKPT VSDSVAASAA ATTPATSPPA VNTSPSAPTP
TTTTEEQVNE PKKWNLRRNR PLLDFVSMEE LNDMDDYDSE DDNDWRPTVV KRKGRSASQK
EGSDGDIEDD EDEGSGSDED ENDEGNDEDH SSPASEGGCK KKKSKVLSRN SADDEELTND
SLTLSQSKSN EDSLILEKSQ NWSSQKMDHI LICCVCLGDN SEDADEIIQC DNCGITVHEG
CYGVDGESDS IMSSASENST EPWFCDACKC GVSPSCELCP NQDGIFKETD AGRWVHIVCA
LYVPGVAFGD IDKLRPVTLT EMNYSKYGAK ECSFCEDPRF ARTGVCISCD AGMCRAYFHV
TCAQKEGLLS EAAAEEDIAD PFFAYCKQHA DRLDRKWKRK NYLALQSYCK MSLQEREKQL
SPEAQARINA RLQQYRAKAE LARSTRPQAW VPREKLPRPL TSSASAIRKL MRKAELMGIS
TDIFPVDNSD TSSSVDGRRK HKQPALTADF VNYYFERNMR MIQIQENMAE QKNIKDKLEN
EQEKLHVEYN KLCESLEELQ NLNGKLRSEG QGIWALLGRI TGQKLNIPAI LRAPKERKPS
KKEGGTQKTS TLPAVLYSCG ICKKNHDQHL LLLCDTCKLH YHLGCLDPPL TRMPRKTKNR
RKRSFIPEEE KHEERVPRER RQRQSVLQKK PKAEDLRTEC ATCKGTGDNE NLVSGYP
//
