ID G1THF6_RABIT Unreviewed; 765 AA.
AC G1THF6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Leucine rich repeat containing 49 {ECO:0000313|Ensembl:ENSOCUP00000016366.2};
GN Name=LRRC49 {ECO:0000313|Ensembl:ENSOCUP00000016366.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016366.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000016366.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000016366.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016366.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; G1THF6; -.
DR SMR; G1THF6; -.
DR STRING; 9986.ENSOCUP00000016366; -.
DR PaxDb; 9986-ENSOCUP00000016366; -.
DR Ensembl; ENSOCUT00000027022.3; ENSOCUP00000016366.2; ENSOCUG00000010063.4.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000157011; -.
DR HOGENOM; CLU_019309_0_0_1; -.
DR InParanoid; G1THF6; -.
DR TreeFam; TF324815; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000010063; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 7.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT REGION 419..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 372..405
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 439..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 86946 MW; F5B0680183E213E0 CRC64;
MIPGRYRSVS GRTANNVNCG LHLVIQTSSL PEKHKVEFKL NRETPSFPGR LLQHDLERNY
SSRQGDGRII SPSARSKSSY ISSTTNVTEL CGLDVKTATS SLSAFGDSST QTPSKARIRQ
GCHSAGPNVS GDHINLVSSS MPSFPVLHRP SEEKVLYSDR LTLERQKLTV CPIINGEEHL
RLLNFQHNFI TRIQNLSNLQ RLIFLDLYDN QIEEISGLST LRSLRVLLLG KNRIKKISNL
ENLKNLDVLD LHGNQITKIE NVSHLCDLRV LNLARNLLSH VDNLNGLDSL TELNLRHNQI
SFVRDVDNLP SLQRLFLSFN NISSFDSVSC LADATSLSDI TFDGNPIAQE SWYKHTVLQN
MMQLRQLDMK RITEEERRMA SVVAKKEEEK KRESHKQSLL KEKKRLTINN VARKWDLQQR
GANIATNPER RDCDPSSQDP CQMDGSTVST LPEESGSLDS GLTSAVQGLC ITDTHLVEVD
GDTLSLYGSG ALESLDRNWS VQTAGMVTTV SFTFIEFDEI VQVLPKLKMK FPNSLHLKFK
ETNLVMLQQF NALAQLRRID QLTIDPQGNP VVQFTLWKYY VLFRLSHFSM QKINGAEEPG
LHGEWLSWLR VTQNDLIMAE RLFGILAHVA SSELPQYRLI SILGDARKKQ FRYLLETKGK
KPGIVNEENN DSKRLVGENT NRATLNYTTR DFYNEKLEEI KEKKKFCKVY VEDLVKGATE
INMKNEALQK LWPQMFIELV RDAVMEIRDK NAYMKLCLQQ IAGSK
//