ID G1TIL8_RABIT Unreviewed; 471 AA.
AC G1TIL8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Potassium channel tetramerization domain containing 8 {ECO:0000313|Ensembl:ENSOCUP00000016789.2};
GN Name=KCTD8 {ECO:0000313|Ensembl:ENSOCUP00000016789.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016789.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000016789.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000016789.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000016789.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016789.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02010779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709455.1; XM_002709409.3.
DR AlphaFoldDB; G1TIL8; -.
DR SMR; G1TIL8; -.
DR STRING; 9986.ENSOCUP00000016789; -.
DR Ensembl; ENSOCUT00000026412.2; ENSOCUP00000016789.2; ENSOCUG00000024690.2.
DR GeneID; 100338127; -.
DR KEGG; ocu:100338127; -.
DR CTD; 386617; -.
DR GeneTree; ENSGT00940000161041; -.
DR HOGENOM; CLU_057051_0_1_1; -.
DR InParanoid; G1TIL8; -.
DR OrthoDB; 2912088at2759; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000024690; Expressed in aorta and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR CDD; cd18396; BTB_POZ_KCTD8; 1.
DR CDD; cd22218; H1_KCTD8; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF68; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD8; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 45..155
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 52349 MW; E11F11E0942E16FD CRC64;
MALKDTGSGG STILPISEMV SSSSSPGAPA AAAAPGPCAP SPFPEVVELN VGGQVYVTKH
STLLSVPDSI LASMFSPSSP RGGARRRGEL PRDSRARFFI DRDGFLFRYV LDYLRDKQLA
LPEHFPEKER LLREAEYFQL TDLVKLLSPK VTKQNSLNDE GCQSDLEDNV SQGSTDALLL
RGAAAAAPSG PGAHGGGGAL DKRSGFLTLG YRGSYTTVRD NQADAKFRRV ARIMVCGRIA
LAKEVFGDTL NESRDPDRQP EKYTSRFYLK FTYLEQAFDR LSEAGFHMVA CNSSGTAAFV
NQYRDDKIWS SYTEYIFFRP PQKIVSPKQE HEDRKNDKVT DKGSESGTSC NELSTSSCDS
HSEASTPQDN PPNAQQAAAH QPNTLTLDRP SKKAPVQWMP PPDKRRNSEL FQTLISKSRE
TNLSKKKVCE KLTVEEEMKK CIQDFKKIHI PDYFPERKRQ WQSELLQKYG L
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