ID G1TIT6_RABIT Unreviewed; 149 AA.
AC G1TIT6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Splicing factor 3b subunit 2 {ECO:0000313|Ensembl:ENSOCUP00000016858.1};
GN Name=SF3B2 {ECO:0000313|Ensembl:ENSOCUP00000016858.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016858.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000016858.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000016858.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000016858.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016858.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR EMBL; AAGW02071500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02071501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02071502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709289.1; XM_002709243.3.
DR AlphaFoldDB; G1TIT6; -.
DR MEROPS; I25.012; -.
DR PaxDb; 9986-ENSOCUP00000016858; -.
DR Ensembl; ENSOCUT00000026805.2; ENSOCUP00000016858.1; ENSOCUG00000015722.4.
DR GeneID; 100357550; -.
DR KEGG; ocu:100357550; -.
DR CTD; 1474; -.
DR eggNOG; ENOG502SC50; Eukaryota.
DR GeneTree; ENSGT00390000006734; -.
DR HOGENOM; CLU_118168_0_1_1; -.
DR OMA; ESTECRK; -.
DR OrthoDB; 3667533at2759; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000015722; Expressed in zone of skin and 17 other cell types or tissues.
DR ExpressionAtlas; G1TIT6; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR47033; CYSTATIN-M; 1.
DR PANTHER; PTHR47033:SF1; CYSTATIN-M; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022704};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease inhibitor {ECO:0000256|ARBA:ARBA00022704}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..149
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018551140"
FT DOMAIN 33..147
FT /note="Cystatin"
FT /evidence="ECO:0000259|SMART:SM00043"
SQ SEQUENCE 149 AA; 16359 MW; 8EE5E4E15203C574 CRC64;
MARPNLALAM GLALLAFCLL ALPGDAWAWP RERRTGERQN LSPSDPQVKK AAQAAVAGYN
MGNNSPYFFR DTKVIKAQSQ LVAGIKYYLT MDLGSTACRK SMVTGDHVDL TTCPLAAGVE
EEKLRCDFEI LVVPWQNSSK LLKQDCVPL
//
