ID G1TJY0_RABIT Unreviewed; 638 AA.
AC G1TJY0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Rap guanine nucleotide exchange factor like 1 {ECO:0000313|Ensembl:ENSOCUP00000017260.3};
GN Name=RAPGEFL1 {ECO:0000313|Ensembl:ENSOCUP00000017260.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017260.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017260.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017260.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017260.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017260.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02039700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TJY0; -.
DR SMR; G1TJY0; -.
DR STRING; 9986.ENSOCUP00000017260; -.
DR PaxDb; 9986-ENSOCUP00000017260; -.
DR Ensembl; ENSOCUT00000024849.3; ENSOCUP00000017260.3; ENSOCUG00000023409.3.
DR eggNOG; KOG2378; Eukaryota.
DR GeneTree; ENSGT00940000160144; -.
DR HOGENOM; CLU_028002_2_0_1; -.
DR InParanoid; G1TJY0; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000023409; Expressed in skin of back and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 423..636
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70734 MW; C3C562E0EE8FF371 CRC64;
MKPLEKFLKK QTSQLAGRTV AGGPGGGPGS CGGPGVGGGS GGGSGLTGGP RPLQRRQSVS
RLLLPAFLRE PPAEPELEPP AEEEAGELAG VAEEPGSGGP CWLQLEEVPG PGPLGGGGPL
RSPSSYSSDE LSPGEPLTPP PWAPLGAPER PEHLLHRVLE RLAGGATRDS GASDILLDDI
VLTHSLFLPT EKFLQELHHF VRAGGVEGRE GLGRKQACLA MLLHFLDTFQ GLLQEEEGAG
HIIKDLYLLI MKDESLYQDL REDTLRLHQL VETVELKIPE DSQPPSKQVK PLFRHFRRID
SCLQTRVAFR GSDEIFCRVY MPDHSYVTIR SRLSASVQDI LGSVTEKLQY SEEPAEREES
LILVAVASSG EKVLLQPTED CVFTTLGINS HLFACTRDSY EALVPLPEEI QVSPGDTEIH
RVEPEDVANH LTAFHWELFR CVHEVGTEGG RGWVGAWRRK RSRWFPSSLP LTSKFIKIAA
ICKQNQDLLS FYAVVMGLDN AAVSRLRLTW EKLPGKFKNL FRKFENLTDP CRNHKSYREV
ISKMKPPVIP FVPLILKDLT FLHEGSKTLV DGLVNVEKLH SVAEKVRTIR RYRSRPLCLD
MEASPHHLQT KAYVRQFQVI DNQNLLFELS YKLEANSQ
//
