ID G1TK94_RABIT Unreviewed; 1211 AA.
AC G1TK94;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Alpha kinase 1 {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
GN Name=ALPK1 {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017378.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017378.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017378.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017378.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02021872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02021875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TK94; -.
DR PaxDb; 9986-ENSOCUP00000017378; -.
DR Ensembl; ENSOCUT00000028123.3; ENSOCUP00000017378.2; ENSOCUG00000024991.3.
DR eggNOG; ENOG502QX1X; Eukaryota.
DR GeneTree; ENSGT00940000159753; -.
DR HOGENOM; CLU_007421_0_0_1; -.
DR OMA; KCNEICH; -.
DR TreeFam; TF316085; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000024991; Expressed in aorta and 14 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16969; Alpha_kinase_ALPK1; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR043529; ALPK1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR46747; ALPHA-PROTEIN KINASE 1; 1.
DR PANTHER; PTHR46747:SF1; ALPHA-PROTEIN KINASE 1; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1010..1211
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
FT REGION 499..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 133662 MW; 8544390609FC3231 CRC64;
MNNQRAVVAL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ASLPSELRTL IQEAKEMKWP
FVPEKWQYKQ AVGPEDKTNL QDVIGAGLQP LLAALRASIL ARDCATASAI VFLTDRFLYG
LDVSGKLLQV AKGLHRLQPT TPIAPQVVIR RARISVNSGK LLKAEYILSS LISNNGATGT
WQYSSESDKI LVQSVCIQIR GQILQKLGMW YEAAELIWAS IVGYMTLPQP DKKGISTSLG
ILADIFVSMS KKDYEQFKNN PQINLGLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV
NIRGTCLLSY SSSNDCPPDK KNVYLCEAKD AFEIGLLTKK GDEPVAGKQE LHSFVKAAFG
LTTVHQRLHG ETEVVGIASK LCGEAMAKLY SFSTSSRSQD REALSQEIMS IITQVKDHLQ
VQSFSNLDDK SYVPESFKSR LDKPIMYGQV DFKKILETYS QHHSSVCEVF ESACGNKRND
PQTGVCITAL KTETKNIDTV SATQDKPCSQ KGLGRASSQM AKSDQEKLRK VASRNWTHSG
AVQGSVDQDM ETETEPPGHS VGGGAVQSTS LSDNQSSSSL CELSGSASTS WEEVNYEVDD
WSARKETSKE EHLVDTQCST ALSEELGDRE ARAVHPLSSG LLALSFQPSK GANLGSSQSQ
LHQQMLLATF PSHNTAGSLL ASGAGQTEQV PEGSQETRKP RNTCAHSTPS HSPAFWLTSD
SDGLKSMATF PSVQEEIFEI IDEFPEANCD ATEVHGREKE KEVNTRGTGP TFRESPSWAD
PEGETAESTE NEPLDSRRVT GNSLGNSSML TCCSFAPRWP VQNSDSGRPD DSTGEQGIDP
DASTVDEEGQ PLNSIGVHAT TGQGSYSSWV LMQPPGQRAE SPNSSLRSSP FPVLSEDCTT
TEEGEGPAHA LRCSLSPSSP SAQRLKSPAF FSGSSEGETS WSFLNSSGSS FVSLPGKTRQ
ETLEARTLQP EDFEKLLAGV RHDWLLRRLE NTGMFKPNQL QRAHNALLLK YSKTSELWTA
QETAVYLGEY LHVKKKGRQR NAFWVHHLHQ EETLGRYVGK EYKEEKGLWP HFIDVERQMT
AQHYVMEFNK RLYEHKIPTQ IFYIPSTILL ILEGRTIKGC VSVEPYMLGE FVKLSNNTKV
VKTEYKATEY GLAYGHFSYE YSNHKDVVVD LQGWVTGDGK GLIYLTDPQI HSVDQKTVAT
QFRKEGNFLL L
//