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Database: UniProt
Entry: G1TK94_RABIT
LinkDB: G1TK94_RABIT
Original site: G1TK94_RABIT 
ID   G1TK94_RABIT            Unreviewed;      1211 AA.
AC   G1TK94;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=Alpha kinase 1 {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
GN   Name=ALPK1 {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017378.2, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000017378.2, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017378.2,
RC   ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000017378.2}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017378.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AAGW02021872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02021873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02021874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02021875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G1TK94; -.
DR   PaxDb; 9986-ENSOCUP00000017378; -.
DR   Ensembl; ENSOCUT00000028123.3; ENSOCUP00000017378.2; ENSOCUG00000024991.3.
DR   eggNOG; ENOG502QX1X; Eukaryota.
DR   GeneTree; ENSGT00940000159753; -.
DR   HOGENOM; CLU_007421_0_0_1; -.
DR   OMA; KCNEICH; -.
DR   TreeFam; TF316085; -.
DR   Proteomes; UP000001811; Chromosome 15.
DR   Bgee; ENSOCUG00000024991; Expressed in aorta and 14 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd16969; Alpha_kinase_ALPK1; 1.
DR   Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR   InterPro; IPR004166; a-kinase_dom.
DR   InterPro; IPR043529; ALPK1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR46747; ALPHA-PROTEIN KINASE 1; 1.
DR   PANTHER; PTHR46747:SF1; ALPHA-PROTEIN KINASE 1; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1010..1211
FT                   /note="Alpha-type protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51158"
FT   REGION          499..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          677..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          753..803
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..550
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..767
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        847..896
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1211 AA;  133662 MW;  8544390609FC3231 CRC64;
     MNNQRAVVAL LQECKQVLDQ LLLEAPDVSE EDKSEDQRCR ASLPSELRTL IQEAKEMKWP
     FVPEKWQYKQ AVGPEDKTNL QDVIGAGLQP LLAALRASIL ARDCATASAI VFLTDRFLYG
     LDVSGKLLQV AKGLHRLQPT TPIAPQVVIR RARISVNSGK LLKAEYILSS LISNNGATGT
     WQYSSESDKI LVQSVCIQIR GQILQKLGMW YEAAELIWAS IVGYMTLPQP DKKGISTSLG
     ILADIFVSMS KKDYEQFKNN PQINLGLLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLTAV
     NIRGTCLLSY SSSNDCPPDK KNVYLCEAKD AFEIGLLTKK GDEPVAGKQE LHSFVKAAFG
     LTTVHQRLHG ETEVVGIASK LCGEAMAKLY SFSTSSRSQD REALSQEIMS IITQVKDHLQ
     VQSFSNLDDK SYVPESFKSR LDKPIMYGQV DFKKILETYS QHHSSVCEVF ESACGNKRND
     PQTGVCITAL KTETKNIDTV SATQDKPCSQ KGLGRASSQM AKSDQEKLRK VASRNWTHSG
     AVQGSVDQDM ETETEPPGHS VGGGAVQSTS LSDNQSSSSL CELSGSASTS WEEVNYEVDD
     WSARKETSKE EHLVDTQCST ALSEELGDRE ARAVHPLSSG LLALSFQPSK GANLGSSQSQ
     LHQQMLLATF PSHNTAGSLL ASGAGQTEQV PEGSQETRKP RNTCAHSTPS HSPAFWLTSD
     SDGLKSMATF PSVQEEIFEI IDEFPEANCD ATEVHGREKE KEVNTRGTGP TFRESPSWAD
     PEGETAESTE NEPLDSRRVT GNSLGNSSML TCCSFAPRWP VQNSDSGRPD DSTGEQGIDP
     DASTVDEEGQ PLNSIGVHAT TGQGSYSSWV LMQPPGQRAE SPNSSLRSSP FPVLSEDCTT
     TEEGEGPAHA LRCSLSPSSP SAQRLKSPAF FSGSSEGETS WSFLNSSGSS FVSLPGKTRQ
     ETLEARTLQP EDFEKLLAGV RHDWLLRRLE NTGMFKPNQL QRAHNALLLK YSKTSELWTA
     QETAVYLGEY LHVKKKGRQR NAFWVHHLHQ EETLGRYVGK EYKEEKGLWP HFIDVERQMT
     AQHYVMEFNK RLYEHKIPTQ IFYIPSTILL ILEGRTIKGC VSVEPYMLGE FVKLSNNTKV
     VKTEYKATEY GLAYGHFSYE YSNHKDVVVD LQGWVTGDGK GLIYLTDPQI HSVDQKTVAT
     QFRKEGNFLL L
//
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