ID G1TKE8_RABIT Unreviewed; 508 AA.
AC G1TKE8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017434.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017434.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017434.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017434.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017434.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR EMBL; AAGW02056628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TKE8; -.
DR PaxDb; 9986-ENSOCUP00000017434; -.
DR Ensembl; ENSOCUT00000031225.3; ENSOCUP00000017434.2; ENSOCUG00000023110.3.
DR eggNOG; KOG1198; Eukaryota.
DR GeneTree; ENSGT00940000162916; -.
DR HOGENOM; CLU_026673_3_1_1; -.
DR TreeFam; TF314255; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000023110; Expressed in kidney and 16 other cell types or tissues.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08241; QOR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43677:SF4; QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 192..505
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 82..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 54983 MW; E515E304C8F48DCE CRC64;
MPGVKRALRT RKPIGFGLTG YWKYLGSLVV TAQVYCERSY KRETVRNKNR APAMQIPKHF
ARGAFFIFLL ASGLHVQGIL GEPEARRPRG PGLSARPWQQ TPSATQTPRR SGPRRGRAAP
SLGLQPGRPL GAPRGGSRAV PPFLPSLVTP PGDPRSRAMA AAVCRRRLPW AWLCRSAGQE
VGRHYRAAVC AELKQPLAIR DVAPRPVRPH EVRVDVYFCG VNFADNLVCR GQYQEKPSVP
FVPGMEFSGV VLETGADVNT VKEGDRVIGM SSFNAMAEEC ITDQKSLWKI PEEVSLQEAA
ILPVSYGTAI LALEHRARVQ PGETVLVTAA AGATGLAVMD VATNVLQAKV IAAAGSDEKC
KLAMQRGAQS SVNYTQGSLK EAVRKLVGEG GVNVAVDMVG GDVFLEALRS LAWEGRIVVL
GFAGGNIASL PTNLLLLKNV CAMGLYWGRY KGHNPSVFSK SLSSALQYCQ QGHLRPYTGS
VFKLEEVNDA FLHVIQRKST GKVLLSLK
//
