ID G1TL23_RABIT Unreviewed; 987 AA.
AC G1TL23;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Adhesion G protein-coupled receptor F3 {ECO:0000313|Ensembl:ENSOCUP00000017667.2};
GN Name=ADGRF3 {ECO:0000313|Ensembl:ENSOCUP00000017667.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017667.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017667.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017667.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017667.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017667.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; AAGW02005662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TL23; -.
DR SMR; G1TL23; -.
DR STRING; 9986.ENSOCUP00000017667; -.
DR PaxDb; 9986-ENSOCUP00000010722; -.
DR Ensembl; ENSOCUT00000024956.3; ENSOCUP00000017667.2; ENSOCUG00000012452.4.
DR GeneTree; ENSGT00940000161541; -.
DR HOGENOM; CLU_010357_0_0_1; -.
DR InParanoid; G1TL23; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000012452; Expressed in uterus and 2 other cell types or tissues.
DR ExpressionAtlas; G1TL23; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15253; 7tmB2_GPR113; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR45813:SF2; ADHESION G-PROTEIN COUPLED RECEPTOR F3; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..987
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023913012"
FT TRANSMEM 690..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 924..944
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..397
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 691..945
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 22..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 106037 MW; 36AF43AD18A3B19E CRC64;
MVCLAAPQLL LAVTLPLLGS PGATASQPDQ SQAGGESGQP LNQERGAGES VPVAIYVQLD
SPDETWLPVL SESLTLPTAL PSSSPRTLTG LSLTTVCNVS RQGYISCTCR AGYQWDSSSC
SRHRPCSCSD RHLPCSCLVF EHSKPGYCQL LPPGLPVSYL PAVPGNLSLS SGLQPLGSTL
KLTLSFSQEI SNLTWFLKSP ESANILQPGA QVSLNFSQDQ AVLTVTDMSQ EWAGEYMSYF
EAQGFLWELH QTVSVPLEAS DVAQLLDQPS VTCTGSSGFQ LSCCTPKTPL TYTASWSPGE
DSQASLLHTP SSQCLVLAVP HCPATDTTYT CELQSQGLAP LRVPVFVTIL RDGDVTCPED
SLVVAWNVTK AGHEAQAPCP VGKRGVVKRL CGPDGLWGAI DYSCTDTRLL NLFAKAKLLL
AGRGKPAEKV PKILARMSRL VEEASSPSDL VSLLGTIEAL AKVVATASVQ LNRSALQDLL
TTTDKVLDMD ISSLWTPAQD KEPSASSDLL LALETLARSL CPPDQPFTFN LTNVQLDSQL
YTPSLSPDYR VSLPPVQVQI PQHSLAPHVP NGTNVRITSL LLQKLGQLLP PNYGQELGDA
LYVTSGQILS ISIMAGSQAI NQVKVIMNFG DINGSAHCVF WDYRLFQGNG GWSEEGCQVA
SAQPPPRCIC QHLTAFSILM SQCSVPQAPA LGLLSQVGLG ASIAALLVCL AVYRLVWRVV
VRNKVAYFRH ASLVNMALCL LAADTCFLGS LLFRPETHSP LCLATAFLSH FLYLATFFWM
LAQALVLAHQ LLFVFHQLSK HQVLPIMVIL GYLCPLGFAG LTLGLYLPRG QYLREGECWL
DGKGGALYTF VGPVLVVVGV NGLVLAMAVL KLLRPSLSEG PPAEKRQALL GVAKALLILT
PIFGLTWGLG LATLLEEVSI VPHYIFTILN AFQGVFILLF GCLMDKKVRE ALRKRFCGTQ
APSSAISLAT NETQVLDHSR GGSEDSR
//
