ID G1TLM5_RABIT Unreviewed; 878 AA.
AC G1TLM5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 21 {ECO:0000256|ARBA:ARBA00020102};
DE AltName: Full=Coiled-coil domain-containing protein 128 {ECO:0000256|ARBA:ARBA00031617};
DE AltName: Full=KLRAQ motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031361};
GN Name=PPP1R21 {ECO:0000313|Ensembl:ENSOCUP00000017877.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000017877.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000017877.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000017877.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000017877.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000017877.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; AAGW02006273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709766.1; XM_002709720.3.
DR AlphaFoldDB; G1TLM5; -.
DR PaxDb; 9986-ENSOCUP00000017877; -.
DR Ensembl; ENSOCUT00000030821.3; ENSOCUP00000017877.2; ENSOCUG00000006967.4.
DR GeneID; 100344047; -.
DR KEGG; ocu:100344047; -.
DR CTD; 129285; -.
DR eggNOG; KOG4421; Eukaryota.
DR GeneTree; ENSGT00390000006820; -.
DR HOGENOM; CLU_022372_0_0_1; -.
DR OMA; NLHTYTE; -.
DR OrthoDB; 2882462at2759; -.
DR TreeFam; TF320535; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000006967; Expressed in left lung and 17 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR InterPro; IPR040024; PPP1R21.
DR InterPro; IPR049372; PPP1R21_C.
DR InterPro; IPR019343; PPP1R21_N.
DR InterPro; IPR019348; PPP1R21_six_helix.
DR PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR Pfam; PF10205; KLRAQ; 1.
DR Pfam; PF21636; PPP1R21_C; 1.
DR Pfam; PF10212; PPP1R21_helical; 1.
DR SMART; SM01254; KLRAQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 110..210
FT /note="Protein phosphatase 1 regulatory subunit 21 N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01254"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..171
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 235..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 656..690
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 794..835
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 98035 MW; 65DA38D821523285 CRC64;
MRQDGALGPR AEPRRARRAG AREGGAAALR RRPASGGRSA LGPTPPSSHP ANPEVEEARR
RWPSRQTLAD PSPGASLGLG AGGGAERPGH PGLDGAGEAM ASAELQGKYQ KLAQEYSKLR
AQNQVLKKGV VDEQANSAAL KEQLKMKDQS LRKLQQEMDS LTFRNLQLAK RVELLQDELA
LSEPRGKKNK KSGESSQLSQ EQKSVFDEDL QKKIEENERL HIQFFEADEQ HKHVEAELRS
RLATLETEAA QHQAVVDGLT RKYMETIEKL QNDKAKLEIK SQTLEKEAKE CRLRTEECQL
QLKNLHEDLS GRLEESLSII NEKVPFNDTK YSQYNALNVP LHNRRHQLKM RDIAGQALAF
VQDLVTALLN FHTYTEQRIQ IFPIDSAIDT ISPLNQKFSQ HLHENASYVR PLEDGMLHLF
ESITEDTVTV LETTVKLKTF SEHLTSYICF LRKILPYQLK SLEEECESSL CTSALKARNL
ELSQDMKKLT AVFEKLQTYV ALLALPSTEP DGLLRTNYSS VLTNVGAALH GLHDVVKDIS
KHYSQKATIE HELPTATQKL ITTNDCILSS LVALTNGAGK IASFFSNNVD FFIASLSYGP
KAASGFISPL SAECMLQYKK KAAAYVKALR KPLVESVPYE EALSNRRVLL SSTESREGLA
QQVQQSLEKI SKLEQEKEHW MLEAQLAKIK LEKENQRIAD KLKNTNSGQL VGLAQENAAV
LNAAGQDEAA AKAVSEPVQS TSLIGILTRT SDDEAPDVES REDLIKNHYM ARIVELTSQL
QLADSKSVHF YAECRALSKR LALAEKSKES LTEEMKVASQ NISRLQDELT TTKRSYEDQL
SMMSDHLCSM NETLSKQREE IDTLKMSSKG NSKKNKTR
//
