ID G1TNA9_RABIT Unreviewed; 3295 AA.
AC G1TNA9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dachsous cadherin-related 2 {ECO:0000313|Ensembl:ENSOCUP00000018479.3};
GN Name=DCHS2 {ECO:0000313|Ensembl:ENSOCUP00000018479.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018479.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018479.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000018479.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018479.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018479.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02045950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000010770.4; ENSOCUP00000018479.3; ENSOCUG00000010772.4.
DR GeneTree; ENSGT00940000162999; -.
DR TreeFam; TF330641; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000010772; Expressed in smooth muscle tissue and 9 other cell types or tissues.
DR ExpressionAtlas; G1TNA9; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 26.
DR Gene3D; 2.60.40.60; Cadherins; 26.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 20.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 26.
DR SUPFAM; SSF49313; Cadherin-like; 26.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 26.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2917..2940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..167
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 168..293
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 294..407
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 418..533
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 534..653
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 698..807
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 803..905
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 906..1008
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1011..1117
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1118..1220
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1225..1340
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1329..1434
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1435..1544
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1552..1648
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1649..1753
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1754..1857
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1858..1962
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1963..2067
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2064..2166
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2167..2271
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2271..2371
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2372..2473
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2474..2589
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2590..2692
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2701..2803
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2804..2901
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3013..3069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3132..3153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3022..3058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3295 AA; 356514 MW; FFA62617280E1E51 CRC64;
MSLSGRRMGE GRPQWGSRAG KRLPRPGRRG SPRGRPGGGG AGAPRSLLGL FVHAWLWAAS
GSSAQVFNLS LSVDEGLPPD TLVGDIRAGL PAAQQQEGGG FFLSEDSDDS PLLDDFHVHP
GTGIIRTARR LDREQRDHYS FVAATLLGAV VQVEIRVNDV NDHSPRFPRE SLRLDVSELS
PPGTAFRLPG AHDPDAGLFG TQGYTLVQPV PWPEDPAGPL FQLRYGTPGP PPLPASSSTL
EPLDLVLLRR LDREVAAAHE LQIEAWDGGR PRRTGRLRVE LRVLDENDNP PVFEQDEYRA
AVREDAPPGA EVCRLRATDR DLGPNGHVRY RIRSRQGSGA GAGGGDGAFF AVEELSGVVR
VRRPLDREAQ AWHQLVVEAR DGGAEPEVAT VRVSIAVLDV NDNRPAIHLL FLTEGGAARV
SEGARPGDYV ARVSVSDADG DPEKEEEEAG EPGAGIGSSS VSLSLEGGEG AFALRPGGRP
GVFFLCVEGP LDRESRDLFA LRLVATDAGS PPLSTEETLL LRVADLNDQA PVFSREHYRA
SVSEAAAPGT AVLWVSASDA DEPGTDHARL RYALAQLSPH CAAEAPPPTA ECGPSFTIDP
ESGVISTRRA LDREVQAAVE LRVMAQDLGE PPLSATCLVS VTVDDVNDNE PVFRRQVYNA
TLAEHAAVGH CFLQGGLSAQ AFVRVELEDV NDNHPVFNPS TYVTSISSHA QPGTEVINVL
ATDRDSGSYG RVAYELIPGE LSSLFTIDST TGIIYSTSTL SHLESTTLLL MVSARDGGGL
TAATNADVTI HILQTPLAPA EFERPQYNFA VYEDVPVDSL VGTVKAREPL NSSEPNLYRI
SSGDLDGTFS IHPWLGTIRT QKPLDHEAQP VVVLTVQAQL GSSAACSSTE VNITVIDVND
NHPVFPKASD EITVPQTTAP GTAVYLARAE DKDSGLNGLI RYNIASPNPG IFTIHRELGV
VHLSESLAGH VPRNHTLTLR AQDLGVPPHA ALLLLTVVIE QPQQSPRLAF ENLVYQVEVS
ESLSLMTQIL QIQAYPLGPQ PIMSQVVYSL EPIVSSAVFG VHPYTGWIYL RRQLDYESTQ
AYTFRAFAWI PEDRLLQNVS TSVIVHVLDE NDNPPTFLHG VLFLKVEESP APQGVLGKIT
AIDADSGKNG QLSYFLLSDG KFFKMNPNTG ELISWVALDR EHQTHHQVTV LVTDHGSPPR
NATMAVYVTV TDVNDNRPLF PQCLPGEELH VKVLEGQPVN MLVTTVFAKD LDEGNNAEVI
YSVASDQSDH FKIDANSGEV RTTRILSYDH RASYRMTVVA SDQGVPPLQG QAVVNIQVIP
LSTGRVTIAQ NIRHLVIPEN LKPAKVMSLR KPPDHLQHHN GKLHFSIAAD DSDGPFDVDS
TTGDVFLAKE LDYEFRSHYL FRVVAKDYSR DPIPSSTVFL SIDVEDQNDH SPSFQEELIV
ISVEENVPIG TLVYVFNAKD GDGSFLNSRI QYSIESHHPG VNPFLIHPSF GTLVTAAALD
RESVATVTLT VTASDQAVNV TDRRVASLIA KVVILDVNDH SPTIVSSPVA HVREDAVVGS
LVHRVTARDP DAGRNGKVTY SILSGNENKA FALDKSSGLL TTACPLDYET TSQHTLTLLA
LDNGIPALSS SQTLTITVLD VNDEAPVFKQ RVYEASVKEN QSPGEFVTRV EAVDGDSGIS
SKLRFEIMPG TSFDSFEINP DTGEVVTTTT FDREVQQVFI LRVLARDGGV PSLSGTTTVL
CTIEDVNDHA PEFIVPSHAI EIPENREPGV VYTVLASDMD AGNNGAVTYH IIGGNTDGYF
AINETSGELS TTQALDREHI SSFTLVLLCS DLGVPPRSSS MEMHIRVLDD NDHGPSFPTL
HYQTSVTEGA QVGTQVLVLS AVDEDEGLNG QVEYFLMDAA SGAFTIDPTA GTVRTGHTLD
REARSQHTFK AVARDRSTQG SRSTTVLITV CVTDVNDNDP VWDQNPLDVF LSSWSAPNQT
AAILRAKDLD LGPNGTVTFG FAETQTVFSI DHYTGEIQLQ QSPSPERFPM WLQLRVTDQG
VPSRTTTGLL VVHMEGEDVK ISFSEHLYEG LVTENCEAGT SVVTVKALAA DSIQDSIEYS
IFSGNEDGVF FLCSHSGQLT VKDPKFLDFE VRNEVQLIVV AESGGQRAYS KVAVLIQDVN
DNLPRFGQSV YQASVSEGQS HNTHVVQVFA TDLDSGLNGL LEYSLVSGNH EEVFQIDALS
GVVTTRVVLD YESSSSYSLT VQATDRGMPR LSATSMINIQ VTDINDNAPS FLISEAVQIA
EDSLPGLIVS RVSVHDVDLN PAFVFNFANE SDPGTKFAID QTTGDVVLVK TLDFEEAAKH
ELLIQVSDWV HLTKGALTVH VLDVNDNPPI FSQDFYQVTV PESVPLGYSV LTVSATDLES
KENISYRLLS SAEEFAIDPV NGTIFTIRPV LILDGISTIQ FLVEASDGGI PNLRAFTAVE
VEIQDTNNHA PEFTVEYYNL SLSEDALVGS TLVTFSTIDR DWTRENTYVE YSILSGDAQN
SFHVGTSFTH AEYPYQQVGH LVLHHSLDRE AAASHRLVIL ASDRGCPALS ATAVVSVEVL
DVNDNPPEFS SLKYHAHVKE STPLGSHLTV VSADDADVGS HANIVYRIIS GNEKGHFRLE
DETGVLYLMK PLDYEETIRF TLTVQASDEK EHFSFAVVFI NVLDDNDHAP HFLLSSLHCV
VPENLPVPAT VCSANALDFD AGPYGEVTYS IVAPCFGAHG APPGHGLFLI DPFTGDIHAK
QAVDYENGSK YCLTVEAKDK GDAAASMTVW VDIEGLDEFE PVFTQDQYFF SLPEEKEVRQ
PIGRVEASDA DAGVDGVVLY SLGTASPFFS VNETTGSIYL VRAMPLLRSQ VSKDDTMELK
IIAHSPKADS KFASCTVFVN VSFSPAGQHS AVSHGSFSIS LAVSFFVFLL LVCTLIALTL
RHKQKDAVTH SREKKTSPSL DATLRLTGDA SVFKAFHGAQ DCGAETGPAD PTPEWLSLIS
VMEKDMATLY RHSNSSGHCS VEGETAEDKE IQRINEHPYR KDLDSALGDR ESRVPDSGIP
RDSDQLSCLS GDTDVMVTAE ATEISHLSEG RDGGGDGSTP CAQQNVLPQT LQRREAKKGM
PVDASRDSLV MSGDQEARGS APPAPRTSDG EVRGNSTWDC LLSWEPKFQS LASVFNDIAK
LKDEHLHTPS IPKEKRSFVF PPPLITAIAQ PGIKAVPPRM PSAAAGPLLQ RYPRSPLLYH
LGSLPEAMTP SFSPSLSLLT VQTPATSPLL SDGGASGAHV SGTCQELTAE DEVQI
//
