ID G1TP11_RABIT Unreviewed; 675 AA.
AC G1TP11;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Fibronectin leucine rich transmembrane protein 1 {ECO:0000313|Ensembl:ENSOCUP00000018741.2};
GN Name=FLRT1 {ECO:0000313|Ensembl:ENSOCUP00000018741.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018741.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018741.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018741.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018741.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR AlphaFoldDB; G1TP11; -.
DR SMR; G1TP11; -.
DR STRING; 9986.ENSOCUP00000018741; -.
DR PaxDb; 9986-ENSOCUP00000018741; -.
DR Ensembl; ENSOCUT00000022859.2; ENSOCUP00000018741.2; ENSOCUG00000023520.2.
DR eggNOG; ENOG502QWDS; Eukaryota.
DR GeneTree; ENSGT00940000159375; -.
DR HOGENOM; CLU_027624_0_0_1; -.
DR InParanoid; G1TP11; -.
DR TreeFam; TF331598; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000023520; Expressed in frontal cortex and 15 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF15; LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 554..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 438..533
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 675 AA; 73928 MW; E25E0CD81CDB68F1 CRC64;
MGGDKPVACA AATPTATVTA TVVMTTAAMD LRDWLFLCYG LIAFLTEAID STTCPSVCRC
NNGFIYCNDR GLTSIPADIP DDATTLYLQN NRINNAGIPQ DLKTKVSVQV IYLYENDLDE
FPVNLPRSLR ELHLQDNNVR TIARDSLARL PLLEKLHLDD NSVSTVSIEE DAFADSKQLK
LLFLSRNHLS SIPPGLPHTL EELRLDDNRI STIPLHAFKG LNSLRRLVLD GNLLANQRIA
DDTFSRLQNL TELSLVRNSL AAPPLNLPSA HLQKLYLQDN AISHIPYNTL AKMRELERLD
LSNNNLTTLP RGLFDDLGNL AQLLLRNNPW FCGCNLMWLR DWVKARAAVV NVRGLMCQGP
EKVRGMAIKD ITSEMDECLE AGSQGGGTAH VAAKTTASHQ AASTTPQGSL FTLKAKRPGL
RLPDSNIDYP MATGDGAKTL VIHVKPLTAD SIRITWKATL PAASFRLSWL RLGHSPAVGS
ITETLVQGDK TEYLLTALEP KSTYIICMVT METGNTYVAD ETPVCAKAET ADSYGPTTTL
NQEQNAGPMA GLPLAGIIGG AVALVFLFLV LGAICWYVHR AGELLSRERA YNRGSRKKDD
YVESGTKKDN SILEIRGPGL QMLPINPYRA KEEYVVHTIF PSNGSSLCKG THTIGYGTTR
GYRDGGIPDV DYSYT
//
