ID G1TP61_RABIT Unreviewed; 1401 AA.
AC G1TP61;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Spectrin repeat containing nuclear envelope protein 1 {ECO:0000313|Ensembl:ENSOCUP00000018791.2};
GN Name=SYNE1 {ECO:0000313|Ensembl:ENSOCUP00000018791.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018791.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018791.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000018791.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018791.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018791.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
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DR EMBL; AAGW02053463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000032196.2; ENSOCUP00000018791.2; ENSOCUG00000023878.3.
DR GeneTree; ENSGT00940000154481; -.
DR HOGENOM; CLU_004872_1_0_1; -.
DR TreeFam; TF317709; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000023878; Expressed in prefrontal cortex and 17 other cell types or tissues.
DR ExpressionAtlas; G1TP61; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd21241; CH_SYNE1_rpt1; 1.
DR CDD; cd21243; CH_SYNE1_rpt2; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR047290; CH_SYNE1_rpt1.
DR InterPro; IPR047291; CH_SYNE1_rpt2.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR PANTHER; PTHR21524:SF7; SPECTRIN REPEAT CONTAINING, NUCLEAR ENVELOPE 1; 1.
DR Pfam; PF00307; CH; 2.
DR SMART; SM00033; CH; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 27..141
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 185..290
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT COILED 612..639
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1371..1398
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1401 AA; 161965 MW; 386C8D94CB69895E CRC64;
MATSRAASRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV NDLFEDMKDG
VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALRFLE GRKSMYRGSP IKLVNINSTD
IADGRPSIVL GLMWTIILYF QIEELTSNLP QLQSLSGSAS SVDSIVSSET ASPPSKRKVA
TKIHGNAKKT LLKWVQCAAG KQTGIEVKDF GRSWRSGVAF HSVIHAIRPE LVDLEKVRGR
SNRENLEEAF TIAEVQLGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHSGGIDGL
ENEREDRLLL KEMKVWVEQF ERDLTRAQMT ESNLQDKYQS FKHFRVQYEI KRKQIEHLIQ
PIHRDSKLSL DQALLKQSWD RVSSRLFDWH IQLDKSLPAP LGTIGAWLYR AEVALREEVT
VQQVHEETAN TIQRKLEQHK DLFQNTDAHK RAFHEIYRTR TVNGIPVPHD QLEDMAERFH
FVSSTSELHL MKMEFLELKY RLLSLLVLAE SKLKSWIIKY GRRESVELLL QNYISFIENS
KFFEQYEVTY QILKQTAEMY VKADGSVEEA ENVMKFMTET TAQWRNLSVE VRSVRSMLEE
VISNWDRYGN TVASLQAWLE DAEKMLNQSE NAKKDFFRNL PHWIQQHTTM NDAGNFLIET
CDEMVSRDLK QQLLLLNGRW RELFMEVKQY ARADDMDRMK KEYTDCVTVL LSFAAEARKK
FSDPLEVSFM NVKLLIQDLE DIEQRVPVMD AQYKMITKTA HLITKESSQE EANKMFATMS
GLKEQLTKVK ECCSPLLYES QQLLVPLEEL EKQMTCFYDS LGKINEIIAV LEHEAQSSAL
FKQKHQELLA CQESCKKTLT LVEKGSQSVQ KFVTLSNVLK HFDQTKLQRQ IADVHVAFQN
MVKKTGDWKK HVETNSRLMK KFEESRAELE KVLRMAQEGL QEKGDPEELL RRHTEFFSQL
DQRVLNAFLK ACDELTDILP EQEQQGLQEA VRKLHKQWKD LQGEAPYHLL HLKIDVEKNR
FLACVEECRN ELDRETRLVP QEGSEKIIKE HRIFFSDKGP HHLCEKRLQL IEELCVKLPV
RDPVRETPGS CHATLKELRA AIDSTCAKLM ENPDKWQDYT SRFSEFSSWI SAKEMQLKGI
KDEAIHAANH AEVTYVVDEV RSGVTKRGET LGWLKSRLKI LTEVSSEKEA QKQGDELAKL
SSSFKALGSL LSEVEKMLSN FGECVQYKEI VKSSLEDLIS GSKEVQEQAE KILDTENLFE
AQQLLLHHQQ KTKRISAKKK DLQQQIAQAQ QGEGVTLRKW ERFETNKETV VRYLFQTGSS
HERFLSFSSL ESLSSELEQT KEFSKRTENI AVQAENLVKE ASEIPLGPKN KQLLQQQAKS
VKEQVKKLED TLEEEYVLDK S
//
