ID G1TSA4_RABIT Unreviewed; 1846 AA.
AC G1TSA4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSOCUP00000019917.3};
GN Name=SBF2 {ECO:0000313|Ensembl:ENSOCUP00000019917.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000019917.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000019917.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000019917.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000019917.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000019917.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; AAGW02007883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002708855.1; XM_002708809.3.
DR SMR; G1TSA4; -.
DR STRING; 9986.ENSOCUP00000019917; -.
DR PaxDb; 9986-ENSOCUP00000019917; -.
DR Ensembl; ENSOCUT00000021834.3; ENSOCUP00000019917.3; ENSOCUG00000008986.4.
DR GeneID; 100346684; -.
DR KEGG; ocu:100346684; -.
DR CTD; 81846; -.
DR eggNOG; KOG1090; Eukaryota.
DR eggNOG; KOG4471; Eukaryota.
DR GeneTree; ENSGT00940000155385; -.
DR HOGENOM; CLU_002298_1_1_1; -.
DR InParanoid; G1TSA4; -.
DR OrthoDB; 3195274at2759; -.
DR TreeFam; TF318583; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000008986; Expressed in upper lobe of left lung and 15 other cell types or tissues.
DR GO; GO:0005774; C:vacuolar membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR GO; GO:0019208; F:phosphatase regulator activity; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR CDD; cd13339; PH-GRAM_MTMR13; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14589; PTP-MTMR13; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037823; MTMR13_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 7..426
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1106..1581
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1740..1844
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1670..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1846 AA; 207965 MW; 1F86503A5DD932C0 CRC64;
MARLADYFIV VGYDHDKPGS GEGLGKIIQR FPQKDWDDTP FPQGIELFCQ PGGWQLSRER
KQPTFFVVVL TDIDSDRHYC SCLTFYEAEI NLQGTKKEDT ESEEVSGLIQ PAEVFAPKSL
VLVSRLDYPE IFRACLGLIY TVYVDSLNVS LESLIANLCA CLVPAAGGSQ KLFSLGAGDR
QLIQTPLHDS LPVTGTSVAL LFQQLGIQNV LSLFCAVLTE NKVLFHSASF QRLSDACRAL
ESLMFPLKYS YPYIPILPAQ LLEVLSSPTP FIIGVHSIFK TDIHELLDVI IADLDGGTIK
IPECIHLSSL PEPLLHQTQA ALSLILHPDL EVADHAFPPP RTALSHSKML DKEVRAVFLR
LFAQLFQGYR SCLQLIRIHA EPVIHFHKTA FLGQRGLVEN DFLTKVLNGM AFAGFVSERG
PPYRSCDLFD ELVAFEVERI KVEENNPLKM IKHVRELAEQ LFKNENPNPH MAFQKVPRPT
EGSHLRVHIL PFPKINESRV QELIQENLAK NQNAPPATRV EKKCVVPAGP PVVSIMDKVT
TVFNSAQRLE VVRNCISFIF ENKTLETEKT LPAALRALKG KAARQCLTDE LGLHVQQNRA
ILDHQQFDYI IRMMNCTLQD CSSLEEYNIA AALLPLTSAF YRKLAPGVSQ FAYTCVQDHP
IWTNQQFWET TFYSAVQEQV RSLYLSAKED NHAPHLKQKD KLPDDEYQEK TAMDLAAEQL
RLWPTLSKLT QQELVQHEES TVFSQAIHFA NLMVNLLVPL DTSKNKLLRT SAPGDWESGS
NSIVTNSIAG SVAESYDTES GFEDSENDIA NSVVRFITRF IDKVCTESGV TQDHIKSLHC
MIPGIVAMHI ETLEAVHRES RRLPPIQKPK ILRPALLPGE EIVCEGLRVL LDPDGREEAT
GGLLGGPQLL PAEGALFLTT YRILFRGAPH DQLVGEQTVM RSFPIASITK EKKITVQNQL
QQNMQEGLQI TSASFQLIKV AFDEEVSPEV VEIFKKQLMK FRYPQSIFST FAFATGQTTP
QIILPKQKEK NTSFRTFSKT IVKGAKRAGK MTIGRQYLLK KRTGTIVEER VNRPGWNEED
DISVSDESEL PTSTTLKASE KSTMEQLVEK ACFRDYQRLG LGTISGSSSR SKPEYFRITA
SNRMYSLCRS YPGLLVIPQA VQDSSLPRVA RCYRHNRLPV VCWKNSRSGT LLLRAGGFHG
KGVVGLFKSQ NSPQAAPTSL ESSSSIEQEK YLQALLSAVS VHQKLRGNST LTVRPALALS
PGVWASLRSS ARLISSPTSF IDVGARLAGK DHSASFNNST YLQNQLFKRQ AALYIFGEKS
QLRNFKVEFA LNCEFVPVEF HDIRQVKTSF KKLMRACIPS TIPTDSEVTF LKALGDSEWF
PQLHRIMQLA VVVSEVLENG SSALVCLEEG WDITAQVTSL IQVLSDPFYR TLEGFRMLVE
KEWLSFGHKF SQRSSLTLNC QGSGFAPIFL QFLDCVHQVH NQYPTEFEFN LYYLKFLAFH
YVSNRFKTFL LDSDYERLEH GTLFDDKGDK HAKKGVCIWE CIDRMHKRSP IFFNYLYSPV
EIEALKPSVN VSSLKKWDYY IEETLSTGPS YDWVMLTSKH CPSEDPDLPG GAGPQSRRRT
VWPCYDDVSR AQPDALTSLF SEIEKLEHKL NQTPEKWQQL WEKVAMDLKE EPRADRSQRH
PSGSPGIVSA NLPSYHKRSL LQLADSSVAE EQSASLAPSN GVERRAATLY SQYTSRADEN
RSFEGTLYKR GALLKGWKPR WFVLDVTKHQ LRYYDSREDT SCRGHIDLAE VEVVMPACPS
MGAPKHTSDK AFFDLKTSKR VYNFCAQDGQ SAQQWMDRIQ SCISDA
//
