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Database: UniProt
Entry: G1TSK2_RABIT
LinkDB: G1TSK2_RABIT
Original site: G1TSK2_RABIT 
ID   G1TSK2_RABIT            Unreviewed;       473 AA.
AC   G1TSK2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-OCT-2019, entry version 46.
DE   SubName: Full=ETS proto-oncogene 2, transcription factor {ECO:0000313|Ensembl:ENSOCUP00000020018};
GN   Name=ETS2 {ECO:0000313|Ensembl:ENSOCUP00000020018};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020018, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Genome Assembly Team;
RA   Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Assembly Computation and Development Core Team;
RA   Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
RT   rabbit).";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000020018}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020018};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSOCUP00000020018}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020018};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   STRING; 9986.ENSOCUP00000020018; -.
DR   Ensembl; ENSOCUT00000027337; ENSOCUP00000020018; ENSOCUG00000005861.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160202; -.
DR   InParanoid; G1TSK2; -.
DR   OMA; RSWNSQS; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000005861; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       85    170       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      367    447       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      266    291       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   473 AA;  52755 MW;  15CF11F51BF2B085 CRC64;
     MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAAF PSLNEEQTLQ EVPTGLDSLS
     HDSASCELPL LTPCSKAVMS QALKATFSGF QKEQRRLGIP KNPWLWNEQQ VCQWLLWATN
     EFSLVNVNLQ RFGMNGQVLC NLGKERFLEL APDFVGDILW EHLEEMIKEN QEKTEDQHEG
     NSHLNAVPHW INSNTLGFGA EQAPYGVQAQ SYPKGGLLDG MCPSSAASGA LSSEQEFQMF
     PKSRLNTVSV RYCSVTQDFP GANLSLLNGN SGKPKDHDVP ESGPDSFESS ESLLQSWTSQ
     SSLVDVQRVP SFESFEDDCS QSLCLQQADH FLQGLHSGRG SDPVGAKANP VIPAAVPGRP
     SQGSGPIQLW QFLLELLSDK SCQSFISWTG DGWEFKLADP DEVARRWGKR KNKPKMNYEK
     LSRGLRYYYD KNIIHKTSGK RYVYRFVCDL QNLLGFTPEE LHAILGVQPD TED
//
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