ID G1TTT6_RABIT Unreviewed; 375 AA.
AC G1TTT6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000020458.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020458.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020458.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020458.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020458.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020458.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840}.
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DR EMBL; AAGW02037925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02037934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TTT6; -.
DR PaxDb; 9986-ENSOCUP00000020458; -.
DR Ensembl; ENSOCUT00000028015.3; ENSOCUP00000020458.2; ENSOCUG00000023681.3.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157667; -.
DR HOGENOM; CLU_737622_0_0_1; -.
DR OMA; NQQGCYT; -.
DR TreeFam; TF352892; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000023681; Expressed in ovary and 17 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03156; uroplakin_I_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF249; TETRASPANIN-18; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 138..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 375 AA; 41819 MW; A1BA6F7F6B872B3D CRC64;
MHGFGHPPPR QTPRAPVLRM SRLGHSACCS PLSRSMVYPE ASIRRRAGET LGPRGRQRKV
PVGRGARLWR GLLLPWSARL GSWNLTSRTC QRHRLRTSWA DERSEREPYG AQDSILLTPG
ELPRPITMEG DCLNCMKYLM FVFNFFIFLG GACLLGVGIW VMVDPTGFRE IVAATPLLVT
GAYILLAMGG LLFLLGFLGC CGAVRENKCL LLFFFLFILI IFLAELSAAI LAFIFRENLT
REFFTKELTK HYQGNNDTDV FSATWNSVMI TFGCCGVNGP EDFKVASVFR LLALDSEEVP
EACCRREPQA RAGVLLSREE CLLGRSPFLN KQGCYTVILN AFETYVYLAG ALAIGVLAIE
LCVMVFAMCL FRGIQ
//
