ID G1TUN0_RABIT Unreviewed; 655 AA.
AC G1TUN0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Exocyst complex component 7 {ECO:0000256|ARBA:ARBA00026169, ECO:0000256|RuleBase:RU365026};
DE AltName: Full=Exocyst complex component Exo70 {ECO:0000256|RuleBase:RU365026};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020756.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020756.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020756.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020756.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|RuleBase:RU365026}.
CC -!- SIMILARITY: Belongs to the EXO70 family.
CC {ECO:0000256|ARBA:ARBA00006756, ECO:0000256|RuleBase:RU365026}.
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DR AlphaFoldDB; G1TUN0; -.
DR Ensembl; ENSOCUT00000027238.2; ENSOCUP00000020756.2; ENSOCUG00000027404.2.
DR GeneTree; ENSGT00390000003595; -.
DR HOGENOM; CLU_010236_4_0_1; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000027404; Expressed in uterus and 16 other cell types or tissues.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1280.170; Exocyst complex component Exo70; 2.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR004140; Exo70.
DR InterPro; IPR046364; Exo70_C.
DR PANTHER; PTHR12542:SF41; EXOCYST COMPLEX COMPONENT 7; 1.
DR PANTHER; PTHR12542; EXOCYST COMPLEX PROTEIN EXO70; 1.
DR Pfam; PF03081; Exo70_C; 1.
DR Pfam; PF20669; Exo70_N; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 3: Inferred from homology;
KW Exocytosis {ECO:0000256|RuleBase:RU365026};
KW Protein transport {ECO:0000256|RuleBase:RU365026};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365026}.
FT DOMAIN 271..648
FT /note="Exocyst complex subunit Exo70 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03081"
FT REGION 201..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 74663 MW; CCC98C4BC257F683 CRC64;
MVSILSSFES RLMRLENSII PVHKQTENLQ RLQENVEKTL SCLDHVISYY HVASDTERII
REGPTGRLEE YLGSMAKIQK AVEYFQDNSP DSPELNKVKL LFERGKESLE SEFRSLMTRH
SKVVSPVLIL DLIGGDDELE LQEDVGLEHL PESALQDVTR ISRWLAEYGR NQDFMNVYYQ
IRSSQLDRSV KGLKEHFRKS SCSSGVPYSP AVPTKRKDTP TKKPVKRPGT IRKAQNLLKQ
YSQHGLDGKK GGSNLIPLEG RDDALVDTDA YIHCVSAFVK LGQSEYQLLT GIIPEHHQKK
TFDSLIQDAL DGLMLEGENI VSAARKAIIR HDFSTVLTVF PILRHLKQTK PEFDEVLQGT
AASTKNKLPS LITSMETVGA KALEDFADNI KNDPDKEYNM PKDGTVHELT SNAILFLQQL
LDFQETAGAM LASQVLGDTY NIPLDPRETS SSATSYSSEF SRRLLSTYVC KVLGNLQLNL
LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELMQLVAVT QKTAERSYRE HIQQQIQIYQ
RSWIKVIDYI ADKNLPVLQP GVKLRDKERQ MIKERFKGFN DGLEELCKIQ KAWAIPDTEQ
RDKIRQAQKD MVKETYGVFL HRYGSVPFTK NIEKYIKYRV DQVGDMIDRL FDTSA
//
