ID G1TVB3_RABIT Unreviewed; 1390 AA.
AC G1TVB3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=SPATA31/FAM205 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020996.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020996.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020996.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020996.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020996.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May play a role in spermatogenesis.
CC {ECO:0000256|ARBA:ARBA00037695}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the SPATA31 family.
CC {ECO:0000256|ARBA:ARBA00035009}.
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DR EMBL; AAGW02031309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000026851.2; ENSOCUP00000020996.2; ENSOCUG00000025665.2.
DR eggNOG; ENOG502RU0E; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_005668_2_0_1; -.
DR InParanoid; G1TVB3; -.
DR TreeFam; TF338531; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000025665; Expressed in testis.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039509; SPATA31.
DR InterPro; IPR027970; SPATA31F3-like.
DR PANTHER; PTHR21859; ACROSOME-SPECIFIC PROTEIN; 1.
DR PANTHER; PTHR21859:SF55; SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED; 1.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..150
FT /note="SPATA31F3-like"
FT /evidence="ECO:0000259|Pfam:PF15371"
FT DOMAIN 307..466
FT /note="SPATA31"
FT /evidence="ECO:0000259|Pfam:PF14650"
FT DOMAIN 469..721
FT /note="SPATA31"
FT /evidence="ECO:0000259|Pfam:PF14650"
FT REGION 51..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 155612 MW; 4C0825319DCE1E2D CRC64;
MMEGHLPPLK GVSATWLRTS FTSWVVDIIF PILCGVGLFL LILPCLKSDP SSPPARQKGN
VRKSQVQRRG KSRSRKKSTT LKACREFLQE AEEARGLLSL LQSHQGKPPD QDRAPHLLYQ
DFLGEQHEPA LARVHQPHER DASPAIFTSP ASPAPLPSAS CLSQEPHELH SDLQRIPAGP
VPESTPPAAK TFVFLSSLHG RSQQEHVSHR PQETSFWGDP TCRQLEADGS LFVSSDVRKL
LEILISKRVE QMWKAKEDGS LLKEMHPGHC LNSLGNLLRS PRDKQATTIS QPLCGLKNKP
VQPLHPQQLS YPKVFGDHLE QEYSQLFWGL PSLHSESLVA NAYVSRKPLK FKIPSVKFNI
SSSSPVQIQS LPQHLAQPHK LETPHHVPCF PTKQPISSPS EVRTCKTACP TSQQRARSII
PTYNEQMEWP FQKPEKARRA ILSRCQKSQE LTGQPTLNHP QGNQEDTTSC CTFQEKTGSI
LSTENQQIEW PLQKQQEQRR TLVSHFPNPQ EVTGQPTPKL PQGSQASHTY KASSTVPGYS
ISSKLREPPK QQSQVRYFKD KCQDGPPYRA QASWKVIQPQ EQFLQTCQCQ AKDRHQHCQT
CQSSVFTGIG NNEEQIMGSM RSRRIFGKGS IRFKLDKPIK NVGQDRKCSK DIVWSPGSTS
MKFLESKKSE SSLTTSGKGD CENYVTKSSN KKHLEKNLKA HLGRKLGQIQ EGKIPVKVRR
SLFAVNCAAP KFDTHPKPRN CTTSKGQRSF TDTTRELSFL DPHIRLMLET HIIRFRVRQK
WGLHLQALEP RNLNLGAVQS SALTQSAFST SAVRESGAKL RAKAADFLRE LPWKGQREKV
MTKKPVPTLE KCPLSPSPTH KEVQRALKAT PCGSNRKSSV APLTGQPGRL PAQPLTYNLP
GRNWQSRTVH GAGKDCLELS SRQAMTKYEP WEDRGDLGSP DPCCSTRTFM INAGSQSPRE
KKTKEAGEAK EKVSTWEVSV GTSVAAKSHI NVSLKSLESL GMKKTPSPCE NSTDQHPGEP
RQKRRITKEL ELKVEVESEN QPQDTTTNII QQDIPPVLLS DTDVPTSRGP LSISQSVSTS
DISAAFQEPY DPLSRKRSSQ GQQEPRIPKM KDPHKSVIKT FDSPNRREVC KRPKPGEKER
IAGQKILPAH GRSHPAQDRE TGDTLGIKSS PLLPKKGQVP PENHVKKMVC LSPNKKGKGW
GDYLQKVKPS SAISQSKGTV ISRYFVEKKE QEARAIMTFV AKILADKLRL HYGRGSLELS
WAREDAQTLV GRRSPGRKSP LYLEERRVVT EVDFGHQVNP KDQRHLISNR CVRDRDSNWD
SPPRKPVSLG SPCQVRPSVA GASGHLHHYP TERDLEKCVS SCQPGHDSHT FYGAKTFLLQ
RCQFVQRKVV
//
