ID G1TW86_RABIT Unreviewed; 462 AA.
AC G1TW86;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=ZPR1 zinc finger {ECO:0000313|Ensembl:ENSOCUP00000021330.1};
GN Name=ZPR1 {ECO:0000313|Ensembl:ENSOCUP00000021330.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021330.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000021330.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000021330.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000021330.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021330.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ZPR1 family.
CC {ECO:0000256|ARBA:ARBA00008354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02009446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TW86; -.
DR SMR; G1TW86; -.
DR STRING; 9986.ENSOCUP00000021330; -.
DR PaxDb; 9986-ENSOCUP00000021330; -.
DR Ensembl; ENSOCUT00000021638.2; ENSOCUP00000021330.1; ENSOCUG00000004619.3.
DR eggNOG; KOG2703; Eukaryota.
DR GeneTree; ENSGT00390000005306; -.
DR HOGENOM; CLU_024138_5_0_1; -.
DR InParanoid; G1TW86; -.
DR OMA; PVQSQKG; -.
DR TreeFam; TF313084; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000004619; Expressed in testis and 18 other cell types or tissues.
DR GO; GO:0015030; C:Cajal body; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0097504; C:Gemini of coiled bodies; IEA:Ensembl.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:1902742; P:apoptotic process involved in development; IEA:Ensembl.
DR GO; GO:0061564; P:axon development; IEA:Ensembl.
DR GO; GO:0030576; P:Cajal body organization; IEA:Ensembl.
DR GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
DR GO; GO:0042023; P:DNA endoreduplication; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IEA:Ensembl.
DR GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0045927; P:positive regulation of growth; IEA:Ensembl.
DR GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0033120; P:positive regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:1990261; P:pre-mRNA catabolic process; IEA:Ensembl.
DR GO; GO:0031641; P:regulation of myelination; IEA:Ensembl.
DR GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR GO; GO:0001834; P:trophectodermal cell proliferation; IEA:Ensembl.
DR Gene3D; 2.60.120.1040; ZPR1, A/B domain; 2.
DR Gene3D; 2.20.25.420; ZPR1, zinc finger domain; 2.
DR InterPro; IPR004457; Znf_ZPR1.
DR InterPro; IPR040141; ZPR1.
DR InterPro; IPR042451; ZPR1_A/B_dom.
DR InterPro; IPR042452; ZPR1_Znf1/2.
DR NCBIfam; TIGR00310; ZPR1_znf; 2.
DR PANTHER; PTHR10876; ZINC FINGER PROTEIN ZPR1; 1.
DR PANTHER; PTHR10876:SF0; ZINC FINGER PROTEIN ZPR1; 1.
DR Pfam; PF03367; zf-ZPR1; 2.
DR SMART; SM00709; Zpr1; 2.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 52..210
FT /note="Zinc finger ZPR1-type"
FT /evidence="ECO:0000259|SMART:SM00709"
FT DOMAIN 260..419
FT /note="Zinc finger ZPR1-type"
FT /evidence="ECO:0000259|SMART:SM00709"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 51170 MW; E9E3D7181D78DCD0 CRC64;
MSASGAVEPG PPGAAAVPAA PSPTAAGPPA AGHLFRPINA EDEEQQPTEI ESLCMNCYRN
GMTRLLLTKI PFFREIIVSS FSCEHCGWDN TEIQSAGRIQ DQGVRYALTV RSSEDMNREV
VKTDSATTRI PELDFEIPAF SQKGALTTVE GLINRAISGL EQDQPTRRAN EDAIAERIDE
FIFRLKELKL MDSPFTLIID DPSGNSFVEN PHAPQKDDAL VITHYSRTPE QEQMLGLQAE
APEEKPEEED LRNEVLQFNT NCPECNAPAQ TNMKLVQIPH FKEVIIMATN CENCGHRTNE
VKSGGAVEPL GTKITLHITE PSDMTRDLLK SETCSVEIPE LEFELGMAVL GGKFTTLEGL
LKDIRELVTK NPFTLGDSSN PGQVEKLQEF SRKLDQIVAG HLKAHFIMND PAGNSYLQNV
YAPEDDPEMK VEHYKRTFDQ NEELGLNDMK TEGYEAGVAP QR
//
