ID G1TWR6_RABIT Unreviewed; 710 AA.
AC G1TWR6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Ribonucleoprotein, PTB binding 1 {ECO:0000313|Ensembl:ENSOCUP00000021513.2};
GN Name=RAVER1 {ECO:0000313|Ensembl:ENSOCUP00000021513.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021513.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000021513.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000021513.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021513.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1TWR6; -.
DR Ensembl; ENSOCUT00000030794.2; ENSOCUP00000021513.2; ENSOCUG00000020918.2.
DR GeneTree; ENSGT00940000160550; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000020918; Expressed in testis and 18 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12663; RRM1_RAVER1; 1.
DR CDD; cd12667; RRM3_RAVER1; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034633; RAVER1_RRM1.
DR InterPro; IPR034635; RAVER1_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23189:SF46; RIBONUCLEOPROTEIN PTB-BINDING 1; 1.
DR PANTHER; PTHR23189; RNA RECOGNITION MOTIF-CONTAINING; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 59..130
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 132..210
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 221..299
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 75341 MW; B0F28F72770E1F62 CRC64;
MAADVSVTHR PPLSPEAGAE VEVGDAAERR APEEELPPLD PEEIRRRLEH TERQFRNRRK
ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL LNGEQAEAAI TAFHHSRLRE
RELSVQLQPT DALLCVANLP PSLTQAQFEE LVRPFGSLER CFLVYSKCSG HSKGYGFAEY
MKKDSAARAK SDLLGKPLGS RTLYVHWTDA GHLTPALLHS RCLCVDRLPP GFSDVDALRQ
ALSAVHTPTF CQLACGQDGQ LKGFAVLEYE TAEMAEEAQQ RADGLALGGS HLRVSFCAPG
PPGRSMLAAL IAAQATALHR GKGLLPEPNL LQLLNNLGPS ASLQLLLNPL LQGRAAPGCW
MGAGRLLGAP PAMPLLNGPA LSTALLQLAL QNQGQKKGLV GLGLTLLSLG GALPPEMPPL
LGPSGGGREA MGLGARPRPS LLPGEAPLPK TLANTALLPQ VSLLGEPPKD YRIPLNPYLN
LHSVLPASSL AGKEARGWGG AGRGRHPAEG PPPNPPAPRG GGGKAFQLKS RLLSPLASAR
LPPEPGLPDS YGFDYPSDGG PRRLFGHPRE PGFGHHRPSR HKVSAARASR GSRWLPASGA
RGRGGPLSHF YSGSPTSYSP AGLQAASKQS HLSKAVGSSP LGSSEGLLGL GPGPNGHSHL
LKTPLGGQKR SFAHLLPSPE PSPEGSYVGQ HSQGLGGHYA DSYLKRKRIF
//
