ID G1TXC6_RABIT Unreviewed; 580 AA.
AC G1TXC6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021727.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000021727.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000021727.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021727.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1TXC6; -.
DR SMR; G1TXC6; -.
DR STRING; 9986.ENSOCUP00000021727; -.
DR Ensembl; ENSOCUT00000027153.3; ENSOCUP00000021727.2; ENSOCUG00000021885.3.
DR GeneTree; ENSGT00940000154130; -.
DR HOGENOM; CLU_677149_0_0_1; -.
DR InParanoid; G1TXC6; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000021885; Expressed in lung and 20 other cell types or tissues.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 219..318
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 47..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 63172 MW; 4E45559F5A92F3AD CRC64;
MAEGSKKASR KLKFFKFKGL GSLSNLPRSF TLRRSVAPIS IRSQLKPDTF EATQDDMVTV
PKSPPAYARS SDMYSHMGTM PRPSAKKAQD RQASREPQEG GPEPHLVPQG VPEPLGPEAA
KEVAGADASV EDTAAVDLSA SAVEAEPSGG REDHTENTEE EMAPRDVHPE RAAEEPEAAG
DYVKFSKEKY ILDSSPEKLH KELEEELKLS STDLRSHAWY HGRIPREVSE TLVQRNGDFL
IRDSLTSLGD YVLTCRWRNQ ALHFKINKVV VKAGQNYTHI QYLFEQESFD HVPALVRYHV
GSRKAVSEQS GAIIYCPVNR TFPLRYLEAS YGLSQAGGKA ASPASPSGPK GSHMKRRSVT
VTDGLTADKL TRDACPASAS PAHPRDSIRN CALSMDQIPD LHSPMSPISE SPSSPAYSTG
KAALTRRGSL AAPRCPRVSH GHGLFLQPWL AEPLHGGGQR LSPQGGRARP CQGHRGWDSE
FSNHRRLAPE LIVRAWPADD MVNVHVALGR EGSGCQALVQ GFPECLGIGE ACQRPRVLRA
GAHELRSALG WLLPHLGWGP LVAECVPSPK WPARTGLAGL
//
