ID G1TXQ4_RABIT Unreviewed; 316 AA.
AC G1TXQ4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Carbohydrate sulfotransferase {ECO:0000256|RuleBase:RU364020};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU364020};
GN Name=CHST13 {ECO:0000313|Ensembl:ENSOCUP00000021858.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000021858.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000021858.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000021858.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000021858.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000021858.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU364020}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU364020}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006339, ECO:0000256|RuleBase:RU364020}.
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DR EMBL; AAGW02056219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02056220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TXQ4; -.
DR STRING; 9986.ENSOCUP00000021858; -.
DR PaxDb; 9986-ENSOCUP00000021858; -.
DR Ensembl; ENSOCUT00000022789.2; ENSOCUP00000021858.2; ENSOCUG00000025359.2.
DR eggNOG; KOG4651; Eukaryota.
DR GeneTree; ENSGT00940000161154; -.
DR HOGENOM; CLU_043398_1_1_1; -.
DR InParanoid; G1TXQ4; -.
DR TreeFam; TF325581; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000025359; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047756; F:chondroitin 4-sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0001537; F:N-acetylgalactosamine 4-O-sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:Ensembl.
DR InterPro; IPR018011; Carb_sulfotrans_8-10.
DR InterPro; IPR005331; Sulfotransferase.
DR PANTHER; PTHR12137; CARBOHYDRATE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12137:SF60; CARBOHYDRATE SULFOTRANSFERASE 13; 1.
DR Pfam; PF03567; Sulfotransfer_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU364020};
KW Glycoprotein {ECO:0000256|RuleBase:RU364020};
KW Golgi apparatus {ECO:0000256|RuleBase:RU364020};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|RuleBase:RU364020};
KW Transferase {ECO:0000256|RuleBase:RU364020};
KW Transmembrane {ECO:0000256|RuleBase:RU364020}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..316
FT /note="Carbohydrate sulfotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023926025"
SQ SEQUENCE 316 AA; 36188 MW; 274DACA33570B3D5 CRC64;
MGRRCPRRRM LEAACLGAVL LLLCVAPRAL RPAFESRPLG SGWLSGRRRS PLQILHDLDQ
GPRSPLAEAH RQRRDLLRRA CSRHARRQRL LRPEDLRHVL VDDAHGLLYC YVPKVACTNW
KRVLLALSGR ARGDPRAIPA HEAHAPGRLP SLADFGPAEI NRRLRTYLAF LFVREPFKRL
ASAYRNKFAR PYSEAFQRRY GTRIHTPACG PESPAFLVFF HWERAHALCH PCRLRYDVVG
KFETLAEDAA FVLGLAGAPG LHFPAPPRPR AAAAARDYAA RLFQDISPFY QRRLFDLYKM
DFLLFNYSVP AYLRLH
//
