ID G1TYG2_RABIT Unreviewed; 187 AA.
AC G1TYG2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5 {ECO:0000256|ARBA:ARBA00019580, ECO:0000256|PIRNR:PIRNR037610};
DE Short=BLOC-1 subunit 5 {ECO:0000256|PIRNR:PIRNR037610};
DE AltName: Full=Protein Muted homolog {ECO:0000256|ARBA:ARBA00031992, ECO:0000256|PIRNR:PIRNR037610};
GN Name=BLOC1S5 {ECO:0000313|Ensembl:ENSOCUP00000022126.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022126.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022126.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022126.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022126.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022126.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO).
CC {ECO:0000256|PIRNR:PIRNR037610}.
CC -!- SIMILARITY: Belongs to the BLOC1S5 family.
CC {ECO:0000256|ARBA:ARBA00010754, ECO:0000256|PIRNR:PIRNR037610}.
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DR EMBL; AAGW02052268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002714208.1; XM_002714162.3.
DR AlphaFoldDB; G1TYG2; -.
DR STRING; 9986.ENSOCUP00000022126; -.
DR PaxDb; 9986-ENSOCUP00000022126; -.
DR Ensembl; ENSOCUT00000023691.2; ENSOCUP00000022126.1; ENSOCUG00000025755.2.
DR GeneID; 100354613; -.
DR KEGG; ocu:100354613; -.
DR CTD; 63915; -.
DR eggNOG; ENOG502S2QH; Eukaryota.
DR GeneTree; ENSGT00390000016974; -.
DR HOGENOM; CLU_110751_0_0_1; -.
DR InParanoid; G1TYG2; -.
DR OMA; QGEICYF; -.
DR OrthoDB; 5232538at2759; -.
DR TreeFam; TF332943; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000025755; Expressed in skeletal muscle tissue and 15 other cell types or tissues.
DR GO; GO:0031083; C:BLOC-1 complex; IEA:InterPro.
DR GO; GO:0030133; C:transport vesicle; IEA:InterPro.
DR InterPro; IPR017243; Bloc1s5.
DR PANTHER; PTHR31784; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5; 1.
DR PANTHER; PTHR31784:SF2; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5; 1.
DR Pfam; PF14942; Muted; 1.
DR PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 21746 MW; 50454A4C8822E88E CRC64;
MSGGGEETPV GCEVPTGGGG KKRDSLGTAG SAHLIIKDLG EIHSRLLDHR PVIQGETRYF
VKEFEEKRGL REMRVLENLK NMIHETNEHT LPKCRETMQD NLQQVLQRLQ AANDSVCRLQ
QREQERKKMY NDRLVANEKR RSLQWEEFMK EQPQKRAAVD EEHRKAVARL REQYAEMQKD
LAKFATF
//
