ID G1TYG9_RABIT Unreviewed; 636 AA.
AC G1TYG9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Membrane palmitoylated protein 4 {ECO:0000313|Ensembl:ENSOCUP00000022133.2};
GN Name=MPP4 {ECO:0000313|Ensembl:ENSOCUP00000022133.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022133.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022133.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022133.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022133.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022133.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR EMBL; AAGW02042203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017198522.1; XM_017343033.1.
DR AlphaFoldDB; G1TYG9; -.
DR SMR; G1TYG9; -.
DR STRING; 9986.ENSOCUP00000022133; -.
DR Ensembl; ENSOCUT00000029372.2; ENSOCUP00000022133.2; ENSOCUG00000012470.4.
DR GeneID; 100349491; -.
DR KEGG; ocu:100349491; -.
DR CTD; 58538; -.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000156444; -.
DR HOGENOM; CLU_001715_5_0_1; -.
DR InParanoid; G1TYG9; -.
DR OrthoDB; 2873706at2759; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000001811; Chromosome 7.
DR Bgee; ENSOCUG00000012470; Expressed in blood and 2 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12034; SH3_MPP4; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035600; MPP4_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF34; MAGUK P55 SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 23..77
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 79..136
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 153..234
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 241..311
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 426..615
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 569..620
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 636 AA; 72422 MW; 8C25293DFD564168 CRC64;
MIQSDRGAAP PDKDRKLSSA AKSENGLSHI LRLVLRELSL FYSRDVNGVC LLYDLLHSPW
LQALLKVYDC LQEFQEKKLA PATHHAQALS REVLELLREA PNSPENQELR RILQAPHSKA
LLSAHDTVAQ KDFEPLLPPL PDNIPESEEA MRIVCLVKNQ QPLGATIKRH ELTGDILVAR
VIHGGLVERS GLLYAGDKLV EVNGISVEGL DPEQVIHILA MSRGTIMFKV VPVSDPPVNS
QKMVYVRAMT DYWPQEDPAI PCMDAGLPFR KGDILQIVDQ NDALWWQARK ITDLATCAGL
IPSKPLLKRK QREFWWSQPY QPHTCSKSTI LISMEEEDDM KIDEKCVEAD EETFESEELS
EDKEEFVGYG EKFFIAGFRR SMRLCRRKSH LSQLRATVCC TGGCYSAVGA PYEEVVRYQR
RPADKHRLIV LVGPSGVGVN ELRRQLIEFN PGHFQSAVPH TTRSKKSYEI NGREYHYVSR
ETFESLIYSH RMLEYGEYKG HLYGTSVDAV QAVLDEGKVC VMDLEPQDIQ MARTQDLKPY
VIFIKPSNMN CMKQSRKNAK IITDYFVDMK FKDEDLQEME DLAQKMEAQF GQFFDYVIVN
DNLQDACARL LSVVQKAQEE PQWVPATWIS SDTESS
//