ID G1TYN7_RABIT Unreviewed; 1612 AA.
AC G1TYN7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=DEP domain containing 5, GATOR1 subcomplex subunit {ECO:0000313|Ensembl:ENSOCUP00000022203.3};
GN Name=DEPDC5 {ECO:0000313|Ensembl:ENSOCUP00000022203.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022203.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022203.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022203.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022203.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022203.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02067691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9986.ENSOCUP00000022203; -.
DR PaxDb; 9986-ENSOCUP00000022203; -.
DR Ensembl; ENSOCUT00000028487.3; ENSOCUP00000022203.3; ENSOCUG00000000594.4.
DR eggNOG; KOG3572; Eukaryota.
DR GeneTree; ENSGT00390000016559; -.
DR HOGENOM; CLU_004411_0_0_1; -.
DR InParanoid; G1TYN7; -.
DR Proteomes; UP000001811; Chromosome 21.
DR Bgee; ENSOCUG00000000594; Expressed in frontal cortex and 15 other cell types or tissues.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990130; C:GATOR1 complex; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:Ensembl.
DR CDD; cd04449; DEP_DEPDC5-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR048255; IML1_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; DEP DOMAIN CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR13179:SF8; GATOR COMPLEX PROTEIN DEPDC5; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 1187..1262
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 427..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 181853 MW; 1CBA73F7C26BE73B CRC64;
MRTTKVYKLV IHKKGFGGSD DELVVNPKVF PHIKLGDIVE IAHPNDEYSP LLLQVKSLKE
DLQKETISVD QTVTQVFRLR PYQDVYVNVV DPKDVTLDLV ELTFKDQYIG RGDMWRLKKS
LVSTCAYITQ KVEFAGIRAQ AGELWVKNEK VMCGYISEDT RVVFRSTSAM VYIFIQMSCE
MWDFDIYGDL YFEKAVNGFL ADLFTKWKEK NCSHEVTVVL FSRTFYDAKS TDEFPEVNRA
SIRQDHKGRF YEDFYKVVVQ NERREEWTSL LVTIKKLFIQ YPVLVRLEQA EGFPQGDNST
SAQGNYLEAI NLSFNVFDKH YINRNFDRTG QMSVVITPGV GVFEVDRLLM ILTKQRMIDN
GIGVDLVCMG EQPLHAVPLF KLHNRSTPRD SRLGDDYNIP HWINHSFYTS KSQLFCNSFT
PRIKLAGKKS ASEKAKNGRV SALGTPKESE NALPIQVDYD AYDAQVFRLP GPSRAQRLAT
CRAVREREHH SGKSASSCDV SCSPSLPSRA LPTEEVRSQA SDDSSLGKSA NILMIPHPHL
HQYEVSSSLG YTSTRDALEN MMEPPQRDSS APGRFHVGSA ESMLHVRPGG YTPQRALINP
FAPSRMPMKL TSNRRRWMHT FPVGPSGEAI QIHHQTRQNM AELQDSGQRD PAHSSAELLE
LAYHEAAGRH STSRQPGDGL SFLSFSGTEE LSASLLSNSG TAMNPRTQNK DSLEDNVSTS
PDPILTLSAP PVVPGFCCTV GVDWKSLTTP ACLPLTTDYF PDRQALQNDY TEGCYDLLPE
ADIDRRDEEG VQMTAQQVFE EFICQRLMQG YQIIVQPKAQ KPNPAVPPPL SSSPLYSRGL
VSRNRPEEED QYWLSMGRTF HKVTLKDKMI TVTRYLPKYP YESAQIHYAY SLCPSHSDSE
FVPCWVEFSH ERLEEYKWNY LDQYICSAGS EDFSLIESLK FWRTRFLLLP ACVTATKRIT
EGEAHCDIYG DRPRADEDEW QLLDGFIRFV EGLNRIRRRH RSDRMMRKGA TMKGLQMTGP
IPTHSLESAG PPVGKKGASA LSALLEMEAS QKCLGDQQAA VLGGKSAAQP AESGSVAMTP
TYVDSPRKDG AFFMEFVRSP RTASSAFYPQ VSLDQTAPPV LDGTSLGITM GQSVDRGNSQ
TLGNAQNVGE QGFPSTNSSD SSSQQQAASS LTSSSTLAEI LEAMKHPSTG VQLLSEQKGL
SPCCFISAEV VHWLVNNVEG VQTQAMAIDI MQKMLEEQLI THASGEAWRT FIYGFYFYKI
VMDKEPDRVT MQQPTTTWHT AGVDDFASFQ RKWFEVAFVA EELLHSEIPA FLLPWLPSRP
ASYASRHSSF SRSFGGRSQA AALLAATVPE QRTVTLDVDV NNRTDRLEWC SCYYHGNFSL
NAAFEIKLHW MAVTAAVLFE MVQGWHRKAT SCGFLLVPVL EGPFALPSYL YGDPLRAQLF
IPLNISCLLK EGSEHLFDSF EPETYWDRMH LFQEAIAHRF GFVQDKYSAS AFNFPAENKP
QYIHVTGTVF LQLPYSKRKF SGQQRRRRNS TSSTNQNMFC EERVGYNWAY NTMLTKTWRS
SATGDEKFAD RLLKDFTDFC GNRDNRLLAF WPAAWRKCTR AAPVRRRCPG TG
//
