ID G1TZ21_RABIT Unreviewed; 942 AA.
AC G1TZ21;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSOCUP00000022340.2};
GN Name=SNX14 {ECO:0000313|Ensembl:ENSOCUP00000022340.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022340.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022340.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022340.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022340.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022340.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AAGW02019264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019266; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TZ21; -.
DR PaxDb; 9986-ENSOCUP00000022340; -.
DR Ensembl; ENSOCUT00000030045.2; ENSOCUP00000022340.2; ENSOCUG00000008929.4.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000008929; Expressed in skin of back and 15 other cell types or tissues.
DR ExpressionAtlas; G1TZ21; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR CDD; cd06877; PX_SNX14; 1.
DR CDD; cd08722; RGS_SNX14; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037436; SNX14_PX.
DR InterPro; IPR037892; SNX14_RGS.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..324
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 356..488
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 581..701
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 942 AA; 109061 MW; 826C4E3BC97CB98E CRC64;
MGVAATSASA GSAASAVPRE MVPWVRSVAG KLKQRLRLDV GREICRQYPL FCFLLLCLSA
ASLLLNRYLH VLMIFWSFVA GVVTFYCSLG PDSLLPNIFF TIKYKPKQLG LQELFPQGHS
CAVCGKVKCK RHRPSLLLEN YQPWLDLKIS SKVDASLSEV FELVLENFVY PWYRDVTDDE
SFVDELRVIL RFFASVLIRR IHKVDIPSII TKKLLKAAMK HIEVIVKARQ KVKNTEFLQQ
AALEEYGPEL HVALRSRRDE LQYLRKLTEL LFPYILPPKA TDCRSLTLLI REILSGSVFL
PSLDFLADPD TVNHLLIIFI DDSPPEKATE PASPLVPFLQ KFAEPRNKKP SVLKLELKQI
REQQDLLFRF MNFLKQEGAV HVLQFCLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY
CLDESIDKIR FDPFIVEEIQ RIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH
SDEYFRQLLR GAESPTRNSK FNRSTQKRGE SFGISRIGSK IKGVFKSTTM EGAMLPNYGL
AEGEDDFIEE GIVVMEDDSP VEAVSTPNTL RNLAAWKISI PYVDFFEDPS SERKEKKERI
PVFCIDVERN DRRAVGHEPE HWSVYRRYLE FYVLESKLTE FHGTFPDAQL PSKRIIGPKN
YEFLKSKREE FQEYLQKLLQ HPELSNSQLL ADFLSPNGGE TQFLDKILPD VNLGKIIKSV
PGKLMKEKGQ HLEPFIMNFI NSCESPKPKP SRPELTILSP TSENNKKLFN DLFKNNANRA
ENTERKQNQN YFMEVMTVEG VYDYLMYVGR VVFQVPDWLH HLLMGARILF KNTLEMYTDY
YLQCKLEQLF QEHRLVSLIT LLRDAIFCEN TEPRSLQDKQ KGAKKTFEEM MNYIPDLIVK
CIGEETKYES IRLLFDALQQ PVLNKQVKTV NTSIQVLGWF GE
//
