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Database: UniProt
Entry: G1TZZ6_RABIT
LinkDB: G1TZZ6_RABIT
Original site: G1TZZ6_RABIT 
ID   G1TZZ6_RABIT            Unreviewed;       450 AA.
AC   G1TZZ6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   05-JUN-2019, entry version 54.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000022670};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022670, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Genome Assembly Team;
RA   Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Assembly Computation and Development Core Team;
RA   Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
RT   rabbit).";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000022670}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022670};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSOCUP00000022670}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022670};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   STRING; 9986.ENSOCUP00000022670; -.
DR   Ensembl; ENSOCUT00000023056; ENSOCUP00000022670; ENSOCUG00000026307.
DR   eggNOG; KOG3629; Eukaryota.
DR   eggNOG; ENOG410ZUT5; LUCA.
DR   GeneTree; ENSGT00940000156012; -.
DR   InParanoid; G1TZZ6; -.
DR   OMA; IHTSTIM; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000026307; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR030748; RGL1.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF199; PTHR23113:SF199; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      331    417       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION       25     90       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G1TZZ6}.
FT   REGION      213    329       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G1TZZ6}.
FT   COMPBIAS    216    250       Polar. {ECO:0000256|MobiDB-lite:G1TZZ6}.
FT   COMPBIAS    264    329       Polar. {ECO:0000256|MobiDB-lite:G1TZZ6}.
SQ   SEQUENCE   450 AA;  48734 MW;  A347679AB431EA39 CRC64;
     MSAPEELLLP AGHCVCSAVQ LRLPVKEDVG RGPQGPRADA GGALGHLLRP QQPLDQPGAA
     DEGREPPSSP NLDSSVKENQ KRSQRRLQLQ KDMGVMQGTV PYLGTFLTDL TMLDTALQDH
     IEGGLINFEK RRRVSGGLGP CLLLCSLCPT AYCMKIHTST IMFLRKNYLP YYIEMNYALS
     CEVEAPAEAS TTSPKPRKSM VKRLSLLFLG PDIMASTTPT KEQPKCTASG SSGESMDSAS
     VSSCESNPSE AEEGPLTPVG TPDEPQKKLS QSSSCSSVHS TDTSSSGMSP SNPLSSPASC
     SSNPKTHRRS VSGTSITSTG QPPVYNQQNE DTCIVRVSVE DGRGNMYKSI MLTSQDKTPA
     VIQRAMLKHN LGSEPAEDYE LVQLLSEDRE LVPDSANVFY AMNTQVNFDF ILRRKSPVDQ
     QVALRSRSSL TLPRTARRGC WGGRHSKVSL
//
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