ID G1U211_RABIT Unreviewed; 453 AA.
AC G1U211;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Armadillo repeat containing X-linked 1 {ECO:0000313|Ensembl:ENSOCUP00000023403.2};
GN Name=ARMCX1 {ECO:0000313|Ensembl:ENSOCUP00000023403.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023403.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000023403.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000023403.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000023403.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023403.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004572}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000256|ARBA:ARBA00010553}.
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DR EMBL; AAGW02046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002720409.1; XM_002720363.3.
DR RefSeq; XP_017205141.1; XM_017349652.1.
DR AlphaFoldDB; G1U211; -.
DR STRING; 9986.ENSOCUP00000023403; -.
DR PaxDb; 9986-ENSOCUP00000023403; -.
DR Ensembl; ENSOCUT00000026664.2; ENSOCUP00000023403.2; ENSOCUG00000028120.2.
DR GeneID; 100351951; -.
DR KEGG; ocu:100351951; -.
DR CTD; 51309; -.
DR eggNOG; ENOG502QYZW; Eukaryota.
DR GeneTree; ENSGT00940000162561; -.
DR HOGENOM; CLU_028273_0_0_1; -.
DR InParanoid; G1U211; -.
DR OrthoDB; 2912889at2759; -.
DR TreeFam; TF335652; -.
DR Proteomes; UP000001811; Chromosome X.
DR Bgee; ENSOCUG00000028120; Expressed in upper lobe of left lung and 17 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR15712; ARMADILLO REPEAT CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15712:SF14; ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 1; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SMART; SM00185; ARM; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00022787};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022787};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 202..422
FT /note="Armadillo repeat-containing"
FT /evidence="ECO:0000259|Pfam:PF04826"
FT REPEAT 247..284
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 132..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 49356 MW; CB7090DA318263B3 CRC64;
MGRTREAGCV AAGVVIGAGA CYCVYKLTWG KDEYEKAWDD DEECSDTSET GVEPEIVASD
AVGEEPVAKL QGESKAEAEV SLELESGPAV KKEAQLGSQS GGGLEAKAKA LFNTLKEQAS
AKLGKGARVG SISGNRTLAP SLPCPGGRGG GCHPPKSGGR SGSRASGKSK GKTRSKSTKA
PATTWPVRRG KFNFPYKIDD ILSTPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ
NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL
DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM
TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KSEGLASSRK EFSRNSLFFL
FKESGVCVKK IRALANHSDL VVKVKVLKVL TKL
//
