ID G1U225_RABIT Unreviewed; 529 AA.
AC G1U225;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000023419.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000023419.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000023419.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000023419.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000023419.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; AAGW02023129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02023130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001182734.1; NM_001195805.1.
DR AlphaFoldDB; G1U225; -.
DR SMR; G1U225; -.
DR Ensembl; ENSOCUT00000028816.3; ENSOCUP00000023419.2; ENSOCUG00000022593.3.
DR GeneID; 100009448; -.
DR KEGG; ocu:100009448; -.
DR CTD; 100009448; -.
DR GeneTree; ENSGT00940000164288; -.
DR HOGENOM; CLU_012949_3_0_1; -.
DR InParanoid; G1U225; -.
DR OMA; PITLCEI; -.
DR OrthoDB; 382054at2759; -.
DR TreeFam; TF315472; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000022593; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF78; UDP-GLYCOSYLTRANSFERASES DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 24..529
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5005131257"
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 529 AA; 60561 MW; 75AFD20508510849 CRC64;
MKAVKGFCVL FTLLLCFVDS GRTGKILVWP MDFSHWINLK VILEELQLRG HEITVLVPSP
SLLLDHTKIP FNVEVLQLQV TKETLMEELN TVLYMSSFEL PTLSWWKVLG KMVEMGKQFS
KNLRRVCDSA ITNKELLDRL KAAKFDICLA DPLAFCGELV AELLNIPFVY SFRFSIGNII
ERSCAGLPTP SSYVPGSTSG LTDNMSFVQR LKNWLLYLMN DMMFSHFMLS EWDEYYSKVL
GRRTTICEIM GKAEMWLIRS YWDFEFPRPF LPNFEYVGGL HCKPAKPLPE ELEEFVQSSG
NDGVVVFTLG SMIQNLTEER SNLIASALAQ IPQKVLWRYT GKKPATLGPN TRLFEWIPQN
DLLGHPKTRA FITHGGTNGL YEAIYHGVPM VGIPLFGDQP DNIARVKAKG AAVDVDLRIM
TTSSLLKALK DVINNPSYKE NAMKLSRIHH DQPLKPLDRA VFWIEFVMRH KGARHLRVAA
HDLTWFQYYS LDVVVFLLTC VATIIFLAKK CCLFFYRRFC KTGNKRKRE
//
