ID G1U4W1_RABIT Unreviewed; 215 AA.
AC G1U4W1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=CDC42 effector protein 2 {ECO:0000313|Ensembl:ENSOCUP00000024436.1};
GN Name=CDC42EP2 {ECO:0000313|Ensembl:ENSOCUP00000024436.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000024436.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000024436.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000024436.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000024436.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004184}.
CC -!- SIMILARITY: Belongs to the BORG/CEP family.
CC {ECO:0000256|ARBA:ARBA00010770}.
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DR RefSeq; XP_008250017.1; XM_008251795.2.
DR AlphaFoldDB; G1U4W1; -.
DR STRING; 9986.ENSOCUP00000024436; -.
DR PaxDb; 9986-ENSOCUP00000024436; -.
DR Ensembl; ENSOCUT00000004586.2; ENSOCUP00000024436.1; ENSOCUG00000004589.2.
DR GeneID; 100358492; -.
DR KEGG; ocu:100358492; -.
DR CTD; 10435; -.
DR eggNOG; ENOG502RY28; Eukaryota.
DR GeneTree; ENSGT00940000161776; -.
DR HOGENOM; CLU_073229_0_0_1; -.
DR InParanoid; G1U4W1; -.
DR OMA; DQDLGHM; -.
DR OrthoDB; 5317319at2759; -.
DR TreeFam; TF331725; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000004589; Expressed in skeletal muscle tissue and 18 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0001515; F:opioid peptide activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR InterPro; IPR029273; Cdc42_effect-like.
DR InterPro; IPR017363; Cdc42_effector_prot_2.
DR InterPro; IPR000095; CRIB_dom.
DR PANTHER; PTHR15344:SF4; CDC42 EFFECTOR PROTEIN 2; 1.
DR PANTHER; PTHR15344; CDC42 EFFECTOR PROTEIN BORG; 1.
DR Pfam; PF14957; BORG_CEP; 2.
DR Pfam; PF00786; PBD; 1.
DR PIRSF; PIRSF038036; Cdc42_effector_p2; 1.
DR SMART; SM00285; PBD; 1.
DR PROSITE; PS50108; CRIB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 30..44
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 117..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 22895 MW; 04E6ED35221881BD CRC64;
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGGD MFGDISFLQG
KLHLLPGTAA AEGPEEDGAY DLPFQFTRTA TVYGRELPDG LSPLLKNAIS LPAMGGPQAL
TLPAAQAPPK PPRLHLESPP RSPQPSPPEA GSVDLWRIPE AGSPPNGLTP EPGAEEPFLS
HASSLLSLHV DLGPSILDDV LQIMEQDLDR VQIPT
//