ID G1U7L3_RABIT Unreviewed; 2749 AA.
AC G1U7L3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSOCUP00000025420.3};
GN Name=LRBA {ECO:0000313|Ensembl:ENSOCUP00000025420.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025420.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000025420.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000025420.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000025420.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025420.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02045879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02045887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000021781.3; ENSOCUP00000025420.3; ENSOCUG00000008453.4.
DR eggNOG; KOG1787; Eukaryota.
DR GeneTree; ENSGT00940000154778; -.
DR HOGENOM; CLU_000218_2_2_1; -.
DR TreeFam; TF354330; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000008453; Expressed in adult mammalian kidney and 15 other cell types or tissues.
DR ExpressionAtlas; G1U7L3; baseline.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1959..2067
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2086..2375
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2661..2702
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 886..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1206..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1098
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1522..1536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2749 AA; 306454 MW; F47734D271DE1DB8 CRC64;
LVGGQFDLEM NFIIQEGESI ICMVDLLEKC DVTCQAEVWS MFTAILKKSI RNLQVCTEVG
LVEKVLGKIE KVDHILADLL VDMLGVLASY NLTVRELKLF FSKLQGDKGQ WPPHAGKLLS
VLKHMPQKYG PDAFFNFPGK SAAAIALPPI AKWPYQNGFT FHTWLRMDPV NNINVDKDKP
YLYCFRTSKG LGYSAHFVGG CLIITSIKSK GKGFQHCVKF DFKPQKWYMV TIVHIYNRWK
NSELRCYVNG ELASYGEITW FVNTSDTFDK CFLGSSETAD ANRVFCGQMT AVYLFSEALN
AAQIFAIYQL GLGYKGTFKF KAESDLFLAE HHKLLLYDGK LSSAIAFTYN PRATDAQLCL
ESSPKDNPSI FVHSPHALML QDVKAVLTHS IQSAMHSIGG VQVLFPLFAQ LDYRQYLSDE
VDLSICSTLL AFIMELLKNS IAMQEQMLAC KGFLVIGYSL EKSSKSHVSR AVLELCLAFS
KYLSNLQNGM PLLKQLCDHI LLNPAIWIHT PAKVQLMLYT YLSTEFIGTV NIYNTIRRVG
TVLLIMHTLK YYYWAVNPQD RSGITPKGLD GPRPNQKEIL SLRAFLLMFI KQLVMKDSGV
KEDELQAILN YLLTMHEDDN LMDVLQLLVA LMSEHPNSMI PAFDQRNGLR VIYKLLASKS
EGIRVQALKA MGYFLKHLAP KRKAEIMLGH GLFSLLAERL MLQTNLITMT TYNVLFEILI
EQICTQVIHK QHPDPDSSVK IQNPQILKVI ATLLRNSPQC PESMEVRRAF LSDMIKLFNN
SRENRRSLLQ CSVWQEWMLS LCYFNPKNSE EQKITEMVYA IFRILLYHAV KYEWGGWRVW
VDTLSITHSK VTFEIHKENL ASMFRGQQGK VDEEIGLSSS GPVPAISGIS RDVPASAGSQ
QSDKKDSPIY PHFTRNSGEN SSNENTSSVE TTSNVELQTH STSIEERKTE QENRELLDEV
TLEETLTNEE LNAGVLEASS DLREPITVSS STFETAGKDT VTISEGTASV SSPSEGDATE
MPELLDKSLV EEEDDDYVEL KVESSPTEET SLPTEGQDNS LSPAASEGSE RLHEASTDCK
LIFQEEDPVT EKPTGTEAQD SEDPGSLHVT ASESSATSLE TTVSQTAVQS GMDQMLEEGK
KTADSAGETN LDTDSHGNVF EASVTSEQKI AKLDVSSVAS DTERLELKAN TSMEAVQPHR
QMLEVPRQQE QPVRGPVPEA VNGQRRDSRS TMFRVPEFKW SQMHQRLLTD LLFSIETDIQ
MWRSHSTKTV MDFVNSSDNV IFVHNTIHLI SQVMDNMVMA CGGILPLLSA ATSATHELEN
IEPTQGLSIE ASVTFLQRLI SLVDVLIFAS SLGFTEIEAE KNMSSGGILR QCLRLVCAVA
VRNCLECQQH SQLKCRGDAA KVLKTIHSMI PVGKSAAKSP VDIVTGDISS RDLDSKQAQF
LALAVVYFIS VLMVSKYRDI LEPQNERRSQ SCKETGSENE TVSLPDVENT PASFSPSTPA
SVEESESTSS ARRRDSGIGE EASTGLGSNV DVTPQAAPPS VSAGPDAISE VLCTLSLEVN
KSQETRNDGG NELDNKATLP VPVSKNVNVK DILRSLVNIP ADGVTVDPAL LPPACLGALG
DHLSVEQSVQ FRSFDRSVIV ATKKAAVLPS TLATSVPANA VSVVSSVDSA QASDVGGESP
GVLLFCFLVY QSITERLEHA LEKAAPLLRE IFVDFAPFLS RTLLGSHGQE LLIEGTSLVC
MKSSSSVVEL VMLLCSQEWQ NSIQKNAGLA FIELVNEGRL LSQTMKDHLV RVANEAEFIL
SRQRAEDIHR HAEFESLCAQ YSADKREEEK MCDHLIRAAK YRDHVTATQL IQKIINILTD
KHGAWGNSAV SRPREFWRLD YWEDDLRRRR RFVRNPLGST HPEATLKTAV EHAADEDILA
KGKQSIKSHA LGNQNSENEI LLEGDDDTLS SVDEKDLENL AGPVSLSTPA QLVAPSVVVQ
GTLSVTSSEL YFEVDEEDPS FKKIDPKILA YTEGLHGKWL FSEIRSIFSR RYLLQNTALE
IFMANRVAVM FNFPDPATVK KVVNYLPRVG IGTSFGLPQT RRISLASPRQ LFKASNMTQR
WQHREISNFE YLMFLNTIAG RSYNDLNQYP VFPWVITNYE SEELDLTLPS NFRDLSKPVG
ALNPKRAAFF AERYESWEDD QVPKFHYGTH YSTASFVLAW LLRIEPFTTY FLNLQGGKFD
HADRTFSSVS RAWRNSQRDT SDIKELIPEF YYLPEMFVNF NNYNLGVMDD GTVVSDVELP
PWAKTSEEFV RINRLALESE FVSCQLHQWI DLIFGYKQQG PEAVRALNVF YYLTYEGAVN
LNSITDPVLR EAVEAQIRSF GQTPSQLLIE PHPPRGSAMQ ASPLMFTDQA QQDVIMVLKF
PSNSPVTHVA ANTQPGLATP AVITVTANRL FAVNKWHNLP AHQGAVQDQP YQLPVEIDPL
IATSTGMHRR QITDLLDQSI QVHSQCFVVT SDNRYILVGG FWDKSFRVYS TDTGKLIQVV
FGHWDVVTCL TRSESYIGGN CYILSGSRDA TLLLWYWNGK SSGVGDNPGS ETTTPRAILT
GHDYEVTCAA VCAELGLVLS GSQEGPCLIH SMNGDLLRTL EGPENCLKPK LIHASREGHC
VIFYENGLFC TFSVNGKLQA TTETDDNIRA VQLSRDGQYL LTGGDHGVVM VWQVSDLKKL
FAYPGCDAGI RAMALSHDQR CIIAGMASGS IVLFYNDFNR WHHEYQTRY
//