ID G1U7T8_RABIT Unreviewed; 173 AA.
AC G1U7T8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Transmembrane protein 208 {ECO:0000256|ARBA:ARBA00015033};
GN Name=TMEM208 {ECO:0000313|Ensembl:ENSOCUP00000025497.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025497.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000025497.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000025497.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000025497.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025497.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May function as a negative regulator of endoplasmic
CC reticulum-stress induced autophagy. {ECO:0000256|ARBA:ARBA00003220}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM208 family.
CC {ECO:0000256|ARBA:ARBA00009950}.
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DR EMBL; AAGW02067912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002711644.1; XM_002711598.3.
DR AlphaFoldDB; G1U7T8; -.
DR STRING; 9986.ENSOCUP00000025497; -.
DR PaxDb; 9986-ENSOCUP00000025497; -.
DR Ensembl; ENSOCUT00000030550.2; ENSOCUP00000025497.2; ENSOCUG00000026215.2.
DR GeneID; 100344816; -.
DR KEGG; ocu:100344816; -.
DR CTD; 29100; -.
DR eggNOG; KOG3269; Eukaryota.
DR GeneTree; ENSGT00390000008139; -.
DR HOGENOM; CLU_094308_3_0_1; -.
DR InParanoid; G1U7T8; -.
DR OrthoDB; 2908595at2759; -.
DR TreeFam; TF318118; -.
DR Proteomes; UP000001811; Chromosome 5.
DR Bgee; ENSOCUG00000026215; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008506; SND2/TMEM208.
DR PANTHER; PTHR13505; TRANSMEMBRANE PROTEIN 208; 1.
DR PANTHER; PTHR13505:SF7; TRANSMEMBRANE PROTEIN 208; 1.
DR Pfam; PF05620; TMEM208_SND2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 51..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 153..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 173 AA; 19658 MW; D1AE078FBDEFC3DA CRC64;
MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWMALGFS
LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL
YIWSFWLLAP GRALYLLWVN VLGPWFTADS AAPAPEHNEK RQRRQERRQM KRL
//
