ID G1U8I3_RABIT Unreviewed; 145 AA.
AC G1U8I3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Epithelial membrane protein 1 {ECO:0000256|ARBA:ARBA00013553, ECO:0000256|RuleBase:RU363088};
GN Name=EMP1 {ECO:0000313|Ensembl:ENSOCUP00000025750.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025750.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000025750.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000025750.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000025750.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025750.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363088}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363088}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC {ECO:0000256|ARBA:ARBA00006864, ECO:0000256|RuleBase:RU363088}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363088}.
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DR EMBL; AAGW02044727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02044728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02044729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1U8I3; -.
DR Ensembl; ENSOCUT00000021095.2; ENSOCUP00000025750.2; ENSOCUG00000022231.2.
DR GeneTree; ENSGT00950000182696; -.
DR HOGENOM; CLU_138632_0_1_1; -.
DR InParanoid; G1U8I3; -.
DR TreeFam; TF330414; -.
DR Proteomes; UP000001811; Chromosome 8.
DR Bgee; ENSOCUG00000022231; Expressed in skin of back and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR003932; EMP_1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671:SF6; EPITHELIAL MEMBRANE PROTEIN 1; 1.
DR PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01454; EPMEMPROT1.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363088};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363088};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363088}.
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
SQ SEQUENCE 145 AA; 15887 MW; CD88B8398709D7B7 CRC64;
MLVLLAAIFV VHIATCVMLF VSTIANVWVV SDSINASVGL WRNCTSGDCS GGLSYGHEDA
LKAVQAFMIL SIIFSVISLI IFVFQLFTME KGNRFFLSGA TMLVCWLCVL IGASIYTHRY
ANGDSNTFDR SHHGYSFILT KKGTS
//
