ID G1U8J3_RABIT Unreviewed; 430 AA.
AC G1U8J3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=RAB3A interacting protein like 1 {ECO:0000313|Ensembl:ENSOCUP00000025760.2};
GN Name=RAB3IL1 {ECO:0000313|Ensembl:ENSOCUP00000025760.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000025760.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000025760.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000025760.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000025760.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEC2 family.
CC {ECO:0000256|ARBA:ARBA00025794}.
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DR RefSeq; XP_008272623.1; XM_008274401.2.
DR AlphaFoldDB; G1U8J3; -.
DR PaxDb; 9986-ENSOCUP00000025760; -.
DR Ensembl; ENSOCUT00000030515.2; ENSOCUP00000025760.2; ENSOCUG00000026271.2.
DR GeneID; 100341895; -.
DR CTD; 5866; -.
DR eggNOG; KOG4324; Eukaryota.
DR GeneTree; ENSGT00940000159102; -.
DR HOGENOM; CLU_038204_1_0_1; -.
DR OrthoDB; 1361004at2759; -.
DR TreeFam; TF313748; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000026271; Expressed in blood and 18 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.5.4880; -; 1.
DR InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR InterPro; IPR009449; Sec2_N.
DR PANTHER; PTHR14430:SF5; GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB-3A; 1.
DR PANTHER; PTHR14430; RABIN3-RELATED; 1.
DR Pfam; PF06428; Sec2p; 1.
DR SUPFAM; SSF144284; Sec2 N-terminal region; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 142..209
FT /note="GDP/GTP exchange factor Sec2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06428"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 124..208
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 430 AA; 47242 MW; A7DCF78744CBE3DA CRC64;
MDDTTEEPSG CPARGSCPVF LAMSSGAVRY APSGLGPALE GSLGEKFWGT DSSPQPDEGL
PPPLPAVPVP WNSAGPCKSR REAPGALVEA CVREEAQGEE GPAAARLDMS RLRSSSMEIR
EKGSEFLKEE LHKAQKELRL KDEECERLSK VREQLERELE ELTASLFEEA HKMVREANMK
QAASEKQLKE ARGKIDMLQA EVTALKTLVI TSTPASPNRE LHPQLLSPTK AGPRKGHSRH
KSISSALCPA VCPTAGHTLT PDKEGKEVDT TLFAEFQAWR ESPTLDKSSP FLERVYREDV
GPCLDFTVQE LSALVRAAVE DNTLTIEPVA LHTLPAVTVA AVECGSANTC ALSGLARACR
HRIRLGDSES HYYISPSSRA RITAVCNFFT YIRYIQQGLV RQDAEPMFWE ITRLRKEMSL
AKLGFFPQEA
//
