ID G1VH12_9BACT Unreviewed; 698 AA.
AC G1VH12;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=HMPREF0666_02695 {ECO:0000313|EMBL:EGW49475.1};
OS Prevotella sp. C561.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=563031 {ECO:0000313|EMBL:EGW49475.1, ECO:0000313|Proteomes:UP000003086};
RN [1] {ECO:0000313|EMBL:EGW49475.1, ECO:0000313|Proteomes:UP000003086}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C561 {ECO:0000313|EMBL:EGW49475.1,
RC ECO:0000313|Proteomes:UP000003086};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Prevotella sp. C561.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGW49475.1}.
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DR EMBL; ADCT01000102; EGW49475.1; -; Genomic_DNA.
DR RefSeq; WP_009012767.1; NZ_JH114152.1.
DR AlphaFoldDB; G1VH12; -.
DR STRING; 563031.HMPREF0666_02695; -.
DR PATRIC; fig|563031.3.peg.2580; -.
DR eggNOG; COG3525; Bacteria.
DR HOGENOM; CLU_007082_5_0_10; -.
DR Proteomes; UP000003086; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..698
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003424385"
FT DOMAIN 26..150
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 154..505
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT DOMAIN 584..685
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|Pfam:PF00754"
FT ACT_SITE 335
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 698 AA; 79915 MW; 441C5220911ABE6A CRC64;
MIKKVFIGAA FLLLSASITQ PVSAQSIIPQ PESITRQQGT FTLAKGLQGV TNLKGEAFKI
LNQYTSDIMS IPFSSVKKPS ADAPLRLICT GTEQEAAMAA DSVSLQGYEL NVTPTAVTIQ
ARTPMGLFYG LQTLRQLEKD RQIPCVKITD TPRFAYRGLM IDCSRHFWWK DEIKKQLDAM
AYFKLDRFHW HLTDGGGWRM EVKKYPRLTE ETAYRTESDW TKWWNGKNRQ YSPDPVRLVC
WKGMNIHGGY YTQEDIKEIV DYAAARHITI IPEIEMPGHS DEVVYAYPEL SCTGKPYTQS
DLCVGKEQTY TFMENVLKEV MQLFPSKYIH IGGDEAERRT WKTCPDCQRV MKDYHLKDVA
ELQSHFTHRI ERFLNDNGRK LLGWDEIMEG TLAPNAAVMS WRGTEAGLTA AKSGHHVVMA
PQEFCYLNMY QDDPMTEPKA QGGYTRLEKT YNYDPIPAAY KGTSLEKYID GVQGCVWTEF
IEEPDHLEYM IYPRLLALAE TGWTKQRTGY ADFRQRVITA TDALKRAGYN AFDIRKEKGA
RPESRSIVQH EALGKPVTYL GRYAEKYRAE GDSTLTNGLR GDWGYLEGRW QGFIDSTGVD
VVVDMGKVTD IRDVRVDFMH LYESVIYTPE TIELMVSDDG KNFKTIDTVR PGIKASEDYL
VYPYKWKGDV KGRYVRVKAL SREKDAWIFT DEIIVNQK
//
