ID   G2E9M3_9FLAO            Unreviewed;       943 AA.
AC   G2E9M3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   31-JUL-2019, sequence version 2.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Insulinase family protein {ECO:0000313|EMBL:EGV44765.2};
GN   ORFNames=BZARG_234 {ECO:0000313|EMBL:EGV44765.2};
OS   Bizionia argentinensis JUB59.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Bizionia.
OX   NCBI_TaxID=1046627 {ECO:0000313|EMBL:EGV44765.2, ECO:0000313|Proteomes:UP000003730};
RN   [1] {ECO:0000313|EMBL:EGV44765.2, ECO:0000313|Proteomes:UP000003730}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JUB59 {ECO:0000313|EMBL:EGV44765.2,
RC   ECO:0000313|Proteomes:UP000003730};
RX   PubMed=18842857; DOI=10.1099/ijs.0.65599-0;
RA   Bercovich A., Vazquez S.C., Yankilevich P., Coria S.H., Foti M.,
RA   Hernandez E., Vidal A., Ruberto L., Melo C., Marenssi S., Criscuolo M.,
RA   Memoli M., Arguelles M., Mac Cormack W.P.;
RT   "Bizionia argentinensis sp. nov., isolated from surface marine water in
RT   Antarctica.";
RL   Int. J. Syst. Evol. Microbiol. 58:2363-2367(2008).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGV44765.2}.
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DR   EMBL; AFXZ01000002; EGV44765.2; -; Genomic_DNA.
DR   RefSeq; WP_040287874.1; NZ_AFXZ01000002.1.
DR   AlphaFoldDB; G2E9M3; -.
DR   STRING; 1046627.BZARG_234; -.
DR   PATRIC; fig|1046627.3.peg.248; -.
DR   eggNOG; COG0612; Bacteria.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000003730; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   PANTHER; PTHR43690:SF21; PROCESSING PROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 2.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003730};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          49..170
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          206..384
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          528..648
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          678..852
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   943 AA;  105135 MW;  424844CCA6966DBF CRC64;
     MMQPKIYTLL AILLLCMSCE DKPKDQAQIL ENDFAIDYEK FTLDNGLEVI LHQDTSDPIV
     AVATIMHVGS NREKPGKTGF AHFFEHMSFN DSENVPVGAN RKMIPEWGGS RNGGTSNDYT
     VYYEVVPKDA FEKILWIDSD RFGYMINTVT ESALEREKQV VKNEKRQRVD NAAYGYTDEI
     IRSNLYPEGH PYNWTVIGSL PDLQAATIED VKEFYNQFYG ASNATLVIAG DIDFDETKSL
     VKKWFGEIPS GPKVEALQPQ PVTLTETKSL YFEDNFAKLP ELRMVFPSVE EYHKDSYALQ
     ILGQLLSGSK NAPLYQVVVE EQKLAPNIGT YQSNSELTGE FKFRVRANAQ IDLDLVKKAI
     DSGLTRFEEN GVNDRDLKRI KAELETGLYQ GVSTVLSKAF QLGQDNEFGG DPSYITKTAK
     LTEAVTADDV MRVYNQYIKN KNYVMTSVVP KGQLDLAVEN AKEATVWIEE VKQNVASEEV
     GQGEEADYEK TVSKYDRSEP AFGELPKFKM PTIWTGNLEN GLSIYGIENN ETPLVQFDIT
     IPGGQLLDPT NKAGVANFLS DLMMEGTANK TPAELEEAIG LLGASIYMYS TNEDFHISGS
     CLAKNFEETI ALVKEIILEP RWDESEFARL KQGLETGLKD RESNPNAIAS IAYSRLLYGQ
     NHPFAIPGSG TLETVKDISM ADLKAYYTNL VPKNANFHIA GAMSKSQTLG VLENLNAWKG
     EAPQLPEFKL PLEVKKNTVY FIDVPDSKQS VFNIGKLALS AKNEEAENLY FANEILGGGS
     SGRLFQTLRI EKGYTYGAYS SIGNSLEVSP FTVSSSVRAN ATLKSLEIIK DMVSNYADDF
     TEEDVALTKN KLLKASTRAY ESLGAKLGIL RNISKYGYSN DFIEQNQAEL IAMTLEDYKT
     IINSYLQEPD MIYVIVGDKA SQWGEVKKLG KPVVELDIFG NPM
//