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Database: UniProt
Entry: G2EGM8_9FLAO
LinkDB: G2EGM8_9FLAO
Original site: G2EGM8_9FLAO 
ID   G2EGM8_9FLAO            Unreviewed;       475 AA.
AC   G2EGM8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=BZARG_2286 {ECO:0000313|EMBL:EGV42413.1};
OS   Bizionia argentinensis JUB59.
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Bizionia.
OX   NCBI_TaxID=1046627 {ECO:0000313|EMBL:EGV42413.1, ECO:0000313|Proteomes:UP000003730};
RN   [1] {ECO:0000313|EMBL:EGV42413.1, ECO:0000313|Proteomes:UP000003730}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JUB59 {ECO:0000313|EMBL:EGV42413.1,
RC   ECO:0000313|Proteomes:UP000003730};
RX   PubMed=18842857; DOI=10.1099/ijs.0.65599-0;
RA   Bercovich A., Vazquez S.C., Yankilevich P., Coria S.H., Foti M.,
RA   Hernandez E., Vidal A., Ruberto L., Melo C., Marenssi S.,
RA   Criscuolo M., Memoli M., Arguelles M., Mac Cormack W.P.;
RT   "Bizionia argentinensis sp. nov., isolated from surface marine water
RT   in Antarctica.";
RL   Int. J. Syst. Evol. Microbiol. 58:2363-2367(2008).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGV42413.1}.
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DR   EMBL; AFXZ01000061; EGV42413.1; -; Genomic_DNA.
DR   RefSeq; WP_008639266.1; NZ_AFXZ01000061.1.
DR   STRING; 1046627.BZARG_2286; -.
DR   EnsemblBacteria; EGV42413; EGV42413; BZARG_2286.
DR   PATRIC; fig|1046627.3.peg.2657; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; 219876at2; -.
DR   Proteomes; UP000003730; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003730};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003730}.
FT   DOMAIN      172    308       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      383    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     180    187       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  54263 MW;  1B6B99197C3AFA57 CRC64;
     MSVTAQSVWE NCLEFIKDNI QPQAYKTWFE PIVAVKFTDN ALSIQVPSKF FYEWLEEHYV
     KILKVALTKQ LGENVKLVYI IKMENTYGNK QPFTERIPSA NRSAVKSQDV DLSLNNKNPE
     LRNPFIIPGI RNVKIESQLN PNYSFENFLE GDSNRLARSA GLAVAAKPGG TSFNPLLIFG
     GVGLGKTHLA HAIGVDIKDK YPEKTVLYIS AEKFTQQYID AVKKNNRIDF IHFYQIIDIL
     IIDDVQFLSG KSGTQDVFFH IFNHLHQNGK QVILTSDKAP VDMQDIEQRL LSRFKWGLSA
     ELQTPDFETR VLILKDKLYR DGVEMPEDII EYVAKHIKSN IRELEGAIIS LIAQSSFNKK
     EITIDLAKQV VEKFVKNTKR EVSIDYIQKI VSDYFQMDVD TLQSKTRKRH IVQARQLAMF
     FAKKYTKASL ASIGSQIGKR DHATVLHACK TVNNLSSTDK QFKKYVDDLT KKLSV
//
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