ID G2FYX8_9FIRM Unreviewed; 380 AA.
AC G2FYX8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN ORFNames=DOT_4944 {ECO:0000313|EMBL:EGW37132.1};
OS Desulfosporosinus sp. OT.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfosporosinus.
OX NCBI_TaxID=913865 {ECO:0000313|EMBL:EGW37132.1, ECO:0000313|Proteomes:UP000004928};
RN [1] {ECO:0000313|EMBL:EGW37132.1, ECO:0000313|Proteomes:UP000004928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OT {ECO:0000313|EMBL:EGW37132.1,
RC ECO:0000313|Proteomes:UP000004928};
RX PubMed=21994931; DOI=10.1128/JB.06018-11;
RA Abicht H.K., Mancini S., Karnachuk O.V., Solioz M.;
RT "Genome Sequence of Desulfosporosinus sp. OT, an Acidophilic Sulfate-
RT Reducing Bacterium from Copper Mining Waste in Norilsk, Northern Siberia.";
RL J. Bacteriol. 193:6104-6105(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGW37132.1}.
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DR EMBL; AGAF01000231; EGW37132.1; -; Genomic_DNA.
DR RefSeq; WP_009623529.1; NZ_AGAF01000231.1.
DR AlphaFoldDB; G2FYX8; -.
DR PATRIC; fig|913865.3.peg.4549; -.
DR eggNOG; COG0381; Bacteria.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000004928; Unassembled WGS sequence.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513}.
FT DOMAIN 32..364
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 380 AA; 43465 MW; A979505F76AD2C41 CRC64;
MEKIRCLTVF GTRLEAIKMA PLVKEFQKFP DRIDNKVCVT AQHRDMLDQV LSIFQIEPEF
DLNIMQHGQT LTQITSRALE KSEKVIVETK PHIVLVHGDT STTFMAALAA FYQRITIGHV
EAGLRTYDKY SPFPEEINRQ LTGNIADLHF APTWISANNL LKEGKKQQNI FMTGNTVIDA
MKTTVRSNFN HPIFDNFGKD YRLIFMTVNS RENIGQPMEN IFRAVLRIVD DHNDVVVVYP
MHRNPAVREL AVRILGNRLR IHLIEPLDVI EAHNFMARSY LILTDSGGVQ EEALSLGVPV
LDLRNTTERP EEIKARTLRL VGTNEEDIYN LSYGLLNHSF VYRTMTSVNN PYGDGHASER
IREAVLYYFG LGERPDNFEG
//
