ID   G2GYR7_9ENTR            Unreviewed;       287 AA.
AC   G2GYR7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=ADP-L-glycero-D-manno-heptose-6-epimerase {ECO:0000313|EMBL:EGY29108.1};
GN   ORFNames=Rin_00009270 {ECO:0000313|EMBL:EGY29108.1};
OS   Candidatus Regiella insecticola 5.15.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; aphid secondary symbionts; Regiella.
OX   NCBI_TaxID=1005043 {ECO:0000313|EMBL:EGY29108.1, ECO:0000313|Proteomes:UP000004116};
RN   [1] {ECO:0000313|EMBL:EGY29108.1, ECO:0000313|Proteomes:UP000004116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R5.15 {ECO:0000313|Proteomes:UP000004116};
RX   PubMed=21948522; DOI=10.1101/gr.125351.111;
RA   Hansen A.K., Vorburger C., Moran N.A.;
RT   "Genomic basis of endosymbiont-conferred protection against an insect
RT   parasitoid.";
RL   Genome Res. 22:106-114(2012).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004713}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGY29108.1}.
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DR   EMBL; AGCA01000239; EGY29108.1; -; Genomic_DNA.
DR   AlphaFoldDB; G2GYR7; -.
DR   PATRIC; fig|1005043.3.peg.827; -.
DR   UniPathway; UPA00958; -.
DR   Proteomes; UP000004116; Unassembled WGS sequence.
DR   GO; GO:0008712; F:ADP-glyceromanno-heptose 6-epimerase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05248; ADP_GME_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR011912; Heptose_epim.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02197; heptose_epim; 1.
DR   PANTHER; PTHR43103:SF3; ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE; 1.
DR   PANTHER; PTHR43103; NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004116}.
FT   DOMAIN          20..208
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   287 AA;  32549 MW;  3F82168F8F65F9EA CRC64;
     MVDDLTEGAK FVNLLGLDIG DYMDKDDFIA SIIAGDDIGD IEAVFHQGAC SSTTEWNGKF
     MLENNYQYSK DVLHFCLDRE IPFLYASSAA IYGSCDKNFI EAPKYERPLN VYGYSKLLFD
     QYVRKMIPEA HSQICGLRYF NVYGSGENHK GNMASVAFHL NNQINAGANP KLFSNSQNFK
     RDFIHVDDVV AVNLWAWNNN ISGIYNCGTG QAASFQTLAD TVVEYHRSNK EKNPTVEYID
     FPETLKNHYQ KFTQADLSKL RAAGYDKTFK NVEQGVKEYM SWLNETA
//