ID G2HGU0_PANTR Unreviewed; 490 AA.
AC G2HGU0; A0A2J8JAZ0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Tektin {ECO:0000256|RuleBase:RU367040};
GN Name=TEKT3 {ECO:0000313|Ensembl:ENSPTRP00000014989.3,
GN ECO:0000313|VGNC:VGNC:9686};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62948.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000014989.3, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:BAK62948.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAK62948.1};
RX PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
RA Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
RA Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S., Hashimoto K.,
RA Kim D.S., Park H.S.;
RT "Major chimpanzee-specific structural changes in sperm development-
RT associated genes.";
RL Funct. Integr. Genomics 11:507-517(2011).
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000014989.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms
CC filamentous polymers in the walls of ciliary and flagellar
CC microtubules. Required for normal sperm mobility.
CC {ECO:0000256|RuleBase:RU367040}.
CC -!- SUBUNIT: Interacts with TEKT1, TEKT2, TEKT4 and TEKT5.
CC {ECO:0000256|ARBA:ARBA00038677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230, ECO:0000256|RuleBase:RU367040}.
CC Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}. Cytoplasmic vesicle, secretory
CC vesicle, acrosome outer membrane {ECO:0000256|ARBA:ARBA00037820};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037820}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the tektin family.
CC {ECO:0000256|ARBA:ARBA00007209, ECO:0000256|RuleBase:RU367040}.
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DR EMBL; AACZ04044800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK305954; BAK62948.1; -; mRNA.
DR RefSeq; NP_001233472.1; NM_001246543.1.
DR RefSeq; XP_009430982.1; XM_009432707.2.
DR RefSeq; XP_016786059.1; XM_016930570.1.
DR STRING; 9598.ENSPTRP00000014989; -.
DR PaxDb; 9598-ENSPTRP00000014989; -.
DR Ensembl; ENSPTRT00000016194.4; ENSPTRP00000014989.3; ENSPTRG00000008794.4.
DR GeneID; 455052; -.
DR KEGG; ptr:455052; -.
DR CTD; 64518; -.
DR VGNC; VGNC:9686; TEKT3.
DR eggNOG; KOG2685; Eukaryota.
DR GeneTree; ENSGT00950000182894; -.
DR HOGENOM; CLU_033588_2_1_1; -.
DR OMA; CMEPISG; -.
DR OrthoDB; 2875854at2759; -.
DR TreeFam; TF320754; -.
DR Proteomes; UP000002277; Chromosome 17.
DR Bgee; ENSPTRG00000008794; Expressed in testis.
DR GO; GO:0002080; C:acrosomal membrane; ISS:CAFA.
DR GO; GO:0005879; C:axonemal microtubule; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0002081; C:outer acrosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0036126; C:sperm flagellum; ISS:CAFA.
DR GO; GO:0060271; P:cilium assembly; ISS:CAFA.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0060378; P:regulation of brood size; ISS:UniProtKB.
DR InterPro; IPR048256; Tektin-like.
DR InterPro; IPR000435; Tektins.
DR PANTHER; PTHR19960; TEKTIN; 1.
DR PANTHER; PTHR19960:SF24; TEKTIN-3; 1.
DR Pfam; PF03148; Tektin; 1.
DR PRINTS; PR00511; TEKTIN.
PE 2: Evidence at transcript level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367040};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367040};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|RuleBase:RU367040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT COILED 424..451
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 490 AA; 56604 MW; 3223C68C8844EF30 CRC64;
MERGGCTLTA TYAHPRPTPT NFLPAISTMA SSYRDRFPHS NLTHSLSLPW RPSTYYKVAS
NSPSVAPYCT RSQRVSENTM LPFVSNRTTF FTRYTPDDWY RSNLTNYQES NTSRHNSEKL
RVDTSRLIQD KYQQTRKTHA DTTQNLGERV NDIGFWKSEI IHELDEMIGE TNALTDVKKR
LERALMETEA PLQVARECLF HREKRMGIDL VHDEVEAQLL TEVDTILCCQ ERMKLHLDKA
IAQLAADRAS QHELEKDLSD KQMAYRIDDK CHHLRNTSDG VGYFRGVERV DATVSVPESW
AKFTDDNILR SQSERAASAK LRDDIENLLV VTANEMWNQF NKVNLSFTNR IAETADAKNK
IQTHLAKTLQ EIFQTEMTIE SIKKAIKDKT AFLKVAQTRL DERTRRPNIE LCRDMAQLRL
VNEVHEVDDT IQTLQQRLRD AEDTLQSLVH IKATLEYDLA VKANSLYIDQ EKCMSMRKSY
PNTLRLVGFC
//
