ID   G2I2C8_KOMMN            Unreviewed;       767 AA.
AC   G2I2C8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Formate dehydrogenase alpha subunit {ECO:0000313|EMBL:BAK82544.1};
GN   OrderedLocusNames=GLX_01320 {ECO:0000313|EMBL:BAK82544.1};
OS   Komagataeibacter medellinensis (strain NBRC 3288 / BCRC 11682 / LMG 1693 /
OS   Kondo 51) (Gluconacetobacter medellinensis).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Komagataeibacter.
OX   NCBI_TaxID=634177 {ECO:0000313|EMBL:BAK82544.1, ECO:0000313|Proteomes:UP000009044};
RN   [1] {ECO:0000313|Proteomes:UP000009044}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 3288 / BCRC 11682 / LMG 1693
RC   {ECO:0000313|Proteomes:UP000009044};
RX   PubMed=22123756; DOI=10.1128/JB.06158-11;
RA   Ogino H., Azuma Y., Hosoyama A., Nakazawa H., Matsutani M., Hasegawa A.,
RA   Otsuyama K., Matsushita K., Fujita N., Shirai M.;
RT   "Complete genome sequence of NBRC 3288, a unique cellulose-nonproducing
RT   strain of Gluconacetobacter xylinus isolated from vinegar.";
RL   J. Bacteriol. 193:6997-6998(2011).
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR   EMBL; AP012159; BAK82544.1; -; Genomic_DNA.
DR   RefSeq; WP_014104133.1; NC_016027.1.
DR   AlphaFoldDB; G2I2C8; -.
DR   STRING; 634177.GLX_01320; -.
DR   KEGG; gxy:GLX_01320; -.
DR   PATRIC; fig|634177.7.peg.134; -.
DR   eggNOG; COG0243; Bacteria.
DR   HOGENOM; CLU_000422_16_1_5; -.
DR   Proteomes; UP000009044; Chromosome.
DR   GO; GO:1990204; C:oxidoreductase complex; IEA:UniProt.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0045333; P:cellular respiration; IEA:UniProt.
DR   CDD; cd02787; MopB_CT_ydeP; 1.
DR   CDD; cd02767; MopB_ydeP; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR037951; MopB_CT_YdeP.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR010046; Mopterin_OxRdtse_a_bac.
DR   InterPro; IPR041953; YdeP_MopB.
DR   NCBIfam; TIGR01701; Fdhalpha-like; 1.
DR   PANTHER; PTHR43105:SF4; PROTEIN YDEP; 1.
DR   PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   PIRSF; PIRSF000144; CbbBc; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          112..486
FT                   /note="Molybdopterin oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00384"
FT   DOMAIN          642..749
FT                   /note="Molybdopterin dinucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01568"
SQ   SEQUENCE   767 AA;  84818 MW;  72A1DD7CAABD56AA CRC64;
     MSNEKTPEYK PYHHPAGGWG AAGATAKVLM EQSVLVKGSR GLLSMNQPGG FKCPSCAFPD
     PDHRKTLEFC ENGAKALAHE ATKGRVTREF FEKYTVTELM QKSDYWLEMQ GRLTEPMRYD
     AQSDRYVPVA WDDAFALIGQ HLRALDSPHQ AEFYTSGRTA NETAFLYSIF VREFGTNNFP
     DCSNMCHEPT SRGLPPAIGI GKGTIVMGDF EHAEAIFVVG QNTGTNSPRM MTNLVEARKR
     GVPIVLINPM PERALIRFTE PQDMLQMGTF GSTPISSEFV HVRIGGDLAI FKGMMKALFE
     AEARGETVLD LDFIHEHTAG LDAVRDDAIG CSWGEITQIS GITEAQIRKI ADIYMKSNAT
     IICYGMGLTQ HQEGSRLIQQ VANLLLLRGN FGKPGAGIAP IRGHSNVQGD RTVGIDEKPT
     DAYLDRVRDA FGFEPPREHG HHVLEAVEAM EAGTAKVFFG MGGNFIRAVP DTDRSYAAMR
     NLNLTVGVAT KLNRGHLVHG KDALILPVVA RSEIIRTEAG EQFVTIEDAM ANVTASRGVF
     EPVTGHVRPE TEIVCRMAMA TLPNSRTPWA DYMVDYTLIR DKIAEVYPEI YANFSERIKN
     PHGFHLDIPP RRRVWNTPNG KANFLVLPGL EVNMPVKDAA MLRLATIRSH DQYNTTIYSN
     SDRYRGVYNT RLVIFMNKDD MAERGLANGD VIGLETYSDD GIRRYVDGLH VLDYPMPRGA
     IAGYYPELNP LLPLDYFDEI SGTPAAKSIP VKVVESVASA PPIQIAG
//